马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效和安全性

发布时间：2018-10-24 23:01

【摘要】：目的探讨马来酸依那普利叶酸片降压、降同型半胱氨酸的临床效果及安全性。方法入选2013年1月~2014年1月原发性中度高血压(2度高血压)患者128例,按治疗方式的不同分观察组和对照组,每组64例。观察组予马来酸依那普利叶酸片与苯磺酸氨氯地平联合治疗,对照组仅服用苯磺酸氨氯地平,均治疗2个月,检测治疗前后同型半胱氨酸水平,比较两组的临床效果、同型半胱氨酸水平变化及不良反应情况。结果观察组和对照组的临床有效率分别为93.7%与73.5%,差异具有统计学意义(P0.05);治疗后观察组的同型半胱氨酸水平显著低于对照组(P0.05);观察组和对照组的不良反应发生率分别为4.7%与9.4%,差异无统计学意义(P0.05)。结论原发性中度高血压(2度高血压)患者采用马来酸依那普利叶酸片与苯磺酸氨氯地平联合治疗,其疗效及安全性均优于单独使用苯磺酸氨氯地平,说明马来酸依那普利叶酸片在降压、降同型半胱氨酸方面效果显著,可靠安全,值得临床推广。
[Abstract]:Objective to investigate the clinical efficacy and safety of enalapril maleate folic acid tablets in lowering blood pressure and homocysteine. Methods from January 2013 to January 2014, 128 patients with primary hypertension (2 degree hypertension) were divided into observation group (n = 64) and control group (n = 64). The observation group was treated with enalapril maleate folic acid tablet combined with amlodipine benzenesulfonic acid, while the control group only took amlodipine benzenesulfonic acid for 2 months. The level of homocysteine was measured before and after treatment, and the clinical effects of the two groups were compared. Changes of homocysteine levels and adverse reactions. Results the clinical effective rates of observation group and control group were 93.7% and 73.5%, respectively, the difference was statistically significant (P0.05), the level of homocysteine in observation group was significantly lower than that in control group (P0.05), and the incidence of adverse reactions in observation group and control group was significantly lower than that in control group (P0.05). There was no significant difference between 4.4% and 9.4% (P0.05). Conclusion Enalapril maleate folate tablets combined with amlodipine benzenesulfonate are more effective and safe than amlodipine benzenesulfonate alone in patients with essential moderate hypertension (2 degree hypertension). The results showed that folic acid tablets of enalapril maleate were effective in lowering blood pressure and homocysteine.
【作者单位】：广西贵港市中西医结合骨科医院;
【分类号】：R544.1

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