血管生成素样蛋白2在下肢动脉粥样硬化闭塞症血浆中的变化及其意义
发布时间：2018-10-29 09:28
【摘要】：目的探讨血管生成素样蛋白2(Angptl2)在下肢动脉粥样硬化闭塞症患者血浆中的水平,以及其在下肢动脉粥样硬化闭塞症不同阶段的变化及其意义。方法分析75例下肢动脉粥样硬化闭塞症患者(病例组)及65例健康体检者(对照组)血浆Angptl2水平。常规检测血生化指标及超敏C反应蛋白,采用酶联免疫分析法测定血浆Angptl2、脂联素水平。结果下肢动脉粥样硬化闭塞症患者血浆Angptl2水平较健康对照显著升高[(13.55±9.17)μg/L比(9.04±4.79)μg/L,P=0.010]。糖尿病人群中,下肢动脉粥样硬化闭塞症患者的血浆Angptl2水平(18.67±9.84)μg/L较对照组(13.01±3.47)μg/L升高(P=0.021)。在重症下肢缺血组Angptl2水平较间歇性跛行组更高[(17.01±10.20)μg/L比(10.53±6.97)μg/L,P=0.003]。Angptl213.67μg/L诊断效果最好,敏感性为60.34%,特异性为81.25%。在病例组中,血浆Angptl2水平与踝-肱指数呈负相关(斯皮尔曼相关系数=-0.244,P=0.035)。结论下肢动脉粥样硬化闭塞症患者的血浆Angptl2水平升高。当疾病进展为重症下肢缺血时,Angptl2水平的升高更为明显,可以作为判断疾病进展程度的潜在生物学标志物。
[Abstract]:Objective to investigate the level of angiopoietin-like protein-2 (Angptl2) in plasma of patients with lower extremity atherosclerosis obliteration and its significance in different stages of lower extremity atherosclerosis obliteration. Methods Plasma Angptl2 levels in 75 patients with lower extremity atherosclerosis obliterans (case group) and 65 healthy controls (control group) were analyzed. Blood biochemical indexes and hypersensitive C reactive protein were detected by routine method. Plasma Angptl2, adiponectin levels were measured by enzyme linked immunosorbent assay (Elisa). Results Plasma Angptl2 levels in patients with lower extremity atherosclerosis obliterans were significantly higher than those in healthy controls [(13.55 卤9.17) 渭 g / L vs (9.04 卤4.79) 渭 g / L]. The plasma Angptl2 level in patients with lower extremity atherosclerosis obliterans was (18.67 卤9.84) 渭 g / L higher than that in the control group (13.01 卤3.47) 渭 g / L (P = 0.021). The level of Angptl2 in severe lower extremity ischemia group was higher than that in intermittent claudication group [(17.01 卤10.20) 渭 g / L vs (10.53 卤6.97) 渭 g / L]. Angptl213.67 渭 g / L was the best in diagnosis, and the sensitivity was 60.34. The specificity was 81.25. In the case group, plasma Angptl2 level was negatively correlated with malleolus brachial index (Spelman correlation coefficient = -0.244 P0. 035). Conclusion Plasma Angptl2 levels in patients with lower extremity atherosclerosis obliterans are elevated. When the disease progresses to severe lower extremity ischemia, the increase of Angptl2 level is more obvious, and it can be used as a potential biomarker to judge the degree of disease progression.
【作者单位】： 中国医学科学院北京协和医学院北京协和医院血管外科;内蒙古自治区人民医院血管外科;首都医科大学附属北京朝阳医院血管外科;首都医科大学生理学与病理生理学系;大连医科大学附属第一医院心血管病研究所心内科;大连医科大学公共卫生学院慢性非传染性疾病预防控制中心;
【基金】：国家自然科学基金(81270390)~~
【分类号】：R543.5
[Abstract]:Objective to investigate the level of angiopoietin-like protein-2 (Angptl2) in plasma of patients with lower extremity atherosclerosis obliteration and its significance in different stages of lower extremity atherosclerosis obliteration. Methods Plasma Angptl2 levels in 75 patients with lower extremity atherosclerosis obliterans (case group) and 65 healthy controls (control group) were analyzed. Blood biochemical indexes and hypersensitive C reactive protein were detected by routine method. Plasma Angptl2, adiponectin levels were measured by enzyme linked immunosorbent assay (Elisa). Results Plasma Angptl2 levels in patients with lower extremity atherosclerosis obliterans were significantly higher than those in healthy controls [(13.55 卤9.17) 渭 g / L vs (9.04 卤4.79) 渭 g / L]. The plasma Angptl2 level in patients with lower extremity atherosclerosis obliterans was (18.67 卤9.84) 渭 g / L higher than that in the control group (13.01 卤3.47) 渭 g / L (P = 0.021). The level of Angptl2 in severe lower extremity ischemia group was higher than that in intermittent claudication group [(17.01 卤10.20) 渭 g / L vs (10.53 卤6.97) 渭 g / L]. Angptl213.67 渭 g / L was the best in diagnosis, and the sensitivity was 60.34. The specificity was 81.25. In the case group, plasma Angptl2 level was negatively correlated with malleolus brachial index (Spelman correlation coefficient = -0.244 P0. 035). Conclusion Plasma Angptl2 levels in patients with lower extremity atherosclerosis obliterans are elevated. When the disease progresses to severe lower extremity ischemia, the increase of Angptl2 level is more obvious, and it can be used as a potential biomarker to judge the degree of disease progression.
【作者单位】： 中国医学科学院北京协和医学院北京协和医院血管外科;内蒙古自治区人民医院血管外科;首都医科大学附属北京朝阳医院血管外科;首都医科大学生理学与病理生理学系;大连医科大学附属第一医院心血管病研究所心内科;大连医科大学公共卫生学院慢性非传染性疾病预防控制中心;
【基金】：国家自然科学基金(81270390)~~
【分类号】：R543.5
【相似文献】
相关期刊论文 前10条
1 刘玉清;;动脉粥样硬化/粥样硬化血栓症:影像学和临床意义[J];中国循环杂志;2007年04期
2 余国膺;活化血小板在动脉粥样硬化形成中起一定作用[J];中国慢性病预防与控制;2003年02期
3 马向波;王彦富;李清贤;;糖化低密度脂蛋白水平与冠脉粥样硬化程度的关系[J];山东大学学报(医学版);2013年12期
4 李伟其;曾龙宏;莫玉前;;蛋白转化酶枯草溶菌素9检测对诊断冠脉粥样硬化的临床意义[J];中国实用医药;2014年13期
5 王敏,李长玉;老年人下肢动脉粥样硬化的危险因素[J];中国心血管杂志;2004年05期
6 袁志敏;;抑郁症状与老年人颈总动脉粥样硬化间关系[J];国外医学(老年医学分册);2008年06期
7 董朱光;粥样硬化切除和球囊扩张去除血管支撑物内内膜增生[J];国外医学(临床放射学分册);1991年03期
8 晏沐阳,雷小莹,马兆龙;主——髂动脉粥样硬化的血管内成形术的进展[J];局解手术学杂志;1998年01期
9 陈美娟;李亮;李华;刘剑;顾立;肖顺汉;黄爱萍;吴章怀;;“国窖·1573”对兔动脉粥样硬化的影响[J];酿酒;2007年01期
10 苏建春;于云华;塔依尔江;李葆华;李洁;;浅谈中西医结合防治下肢动脉粥样硬化的优势[J];中医杂志;2009年09期
相关会议论文 前10条
1 许鹏程;许洪陶;马涧泉;龚兰真;;膳食因素对于以大米——黄豆为主膳的大白鼠血清胆固醇及动，
本文编号：2297301
本文链接：https://www.wllwen.com/yixuelunwen/xxg/2297301.html
最近更新
教材专著
