临床代谢组学及其在冠心病诊疗中的研究进展

发布时间：2018-11-08 10:42

【摘要】：代谢组学是近年来生命科学的热门研究领域,它通过分析生物样品中的代谢物,从机体水平上揭示疾病代谢紊乱特征。越来越多的研究证实将代谢组学运用于临床诊疗的可行性,检测生物体液的"代谢指纹"可以为疾病预防、早期诊断、精准治疗、预后评估和新药发现等提供重要支撑。由此,临床代谢组学(clinical metabolomics)应运而生。临床代谢组学是指结合临床大样本,采用代谢组学和生物信息学等手段,从整体上描绘内源性代谢小分子集合在疾病扰动下的稳态失衡及药物干预下的转归机制,揭示疾病潜在的诊疗生物标志物和可干预靶标的一门学科。本文从临床代谢组学发展历程切入,简述了其分析技术手段和研究内容,并以冠心病为例,总结了临床代谢组学在疾病诊疗中的研究进展。
[Abstract]:Metabonomics is a hot research field in life science in recent years. It reveals the characteristics of metabolic disorders in organism level by analyzing metabolites in biological samples. More and more studies have confirmed the feasibility of applying metabonomics to clinical diagnosis and treatment, and the detection of "metabolic fingerprints" in biological fluids can provide important support for disease prevention, early diagnosis, accurate treatment, prognosis evaluation and new drug discovery. Therefore, clinical metabonomics (clinical metabolomics) came into being. Clinical metabonomics is to describe the homeostasis of endogenous metabolic small molecules under the disturbance of disease and the mechanism of outcome under the intervention of drugs by means of metabonomics and bioinformatics combined with large clinical samples. Reveal potential diagnostic and therapeutic biomarkers of disease and a discipline that can target interventions. Based on the development of clinical metabonomics, this paper briefly describes its analytical techniques and research contents, and summarizes the research progress of clinical metabolomics in the diagnosis and treatment of diseases by taking coronary heart disease as an example.
【作者单位】：中国药科大学临床代谢组学中心;
【基金】：国家自然科学基金资助项目(No.91639115)~~
【分类号】：R541.4

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