高血压前期青年血管内皮功能障碍及其影响因素

发布时间：2018-11-10 15:18

【摘要】：目的探讨社区高血压前期青年血管内皮功能障碍及其影响因素。方法以373名青年作为研究对象,依据血压水平将研究对象分为高血压组(HBP组),高血压前期组(PHT组)和正常血压组(NBP组)。以颈动脉内膜中层厚度(IMT)、血流介导的肱动脉扩张性(FMD)以及肱踝动脉脉搏波传导速度(baPWV)评估血管内皮功能。结果PHT组的IMT、baPWV值均高于NBP组(P均0.05),但与HBP组间无统计学差异(P均0.05)。PHT组的FMD水平高于HBP组(P0.05),但与NBP组间比较无统计学意义(P0.05)。高血压前期青年中,舒张压(β=-0.120,P0.05)、体质量指数(β=-0.115,P0.05)与FMD呈独立负相关;舒张压(β=0.146,P0.05)、餐后2h血糖(β=0.147,P0.05)、高密度脂蛋白胆固醇(β=0.150,P0.05)、腰臀比(β=0.126,P0.05)与IMT呈显著正相关;收缩压(β=0.358,P0.01)、腰围(β=0.254,P0.05)、空腹血糖(β=0.155,P0.05)、餐后2h血糖(β=0.152,P0.05)、血尿酸(β=0.206,P0.05)以及超敏C反应蛋白(β=0.099,P0.05)与baPWV相关。结论高血压前期青年已存在血管内皮功能障碍,多种心血管危险因素在高血压前期血管内皮功能障碍的发生发展中发挥重要作用。
[Abstract]:Objective to investigate the vascular endothelial dysfunction and its influencing factors in prehypertensive youth in community. Methods 373 young people were divided into hypertension group (HBP group), prehypertensive group (PHT group) and normal blood pressure group (NBP group) according to blood pressure level. Vascular endothelial function was evaluated by brachial dilated (FMD) mediated by carotid intima-media thickness (IMT),) and brachial and ankle pulse wave velocity (baPWV). Results the IMT,baPWV value of PHT group was higher than that of NBP group (P 0.05), but there was no significant difference between HBP group and HBP group (P 0.05). PHT group was higher than HBP group (P0.05), but there was no significant difference between). PHT group and NBP group (P0.05). In pre-hypertensive youth, diastolic blood pressure (尾 = -0.120) and body mass index (尾 = -0.115) were negatively correlated with FMD. Diastolic blood pressure (尾 = 0.146), postprandial blood glucose (尾 = 0.147), high density lipoprotein cholesterol (尾 = 0.150) and waist-to-hip ratio (尾 = 0.126) were positively correlated with IMT. Systolic blood pressure (尾 = 0.358), waist circumference (尾 = 0.254), fasting blood glucose (尾 = 0.155), postprandial blood glucose (尾 = 0.152), uric acid (尾 = 0.206), serum uric acid (尾 = 0.206), postprandial blood glucose (尾 = 0.152), fasting blood glucose (尾 = 0.155), postprandial blood glucose (尾 = 0.152). P05) and hypersensitive C-reactive protein (尾 = 0.099 P 0.05) were associated with baPWV. Conclusion there are vascular endothelial dysfunction in prehypertensive youth, and many cardiovascular risk factors play an important role in the occurrence and development of vascular endothelial dysfunction.
【作者单位】：西安交通大学第一附属医院心内科;3201医院心内科;汉中市人民医院心血管病研究所;
【分类号】：R544.1

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