原发性高血压病患者血压波动性与颅内外动脉狭窄的关系研究

发布时间：2018-11-11 14:02

【摘要】：目的探讨原发性高血压病患者血压波动性(BPV)与颅内外动脉狭窄的关系及其对颅内外动脉狭窄发生的预测价值。方法选取2013年8月—2015年10月在北京大学人民医院住院的原发性高血压病患者共80例。对患者进行24 h动态血压监测(ABPM),以血压读数的标准差(SD)代表BPV值。采用CT血管造影(CTA)和/或磁共振血管造影(MRA)诊断患者颅内外动脉的狭窄程度。采用Spearman相关性分析探讨原发性高血压病患者BPV与颅内外动脉狭窄的关系,采用受试者工作特征(ROC)曲线评价24 h BPV预测颅内外动脉狭窄发生的价值。结果Spearman相关分析结果显示,24 h、昼间的BPV与颅内外动脉狭窄呈正相关(P0.05)。24 h收缩压SD对颅内外动脉狭窄预测的ROC曲线下面积为0.712[95%CI(0.595,0.829),P=0.004];24 h舒张压SD对颅内外动脉狭窄预测的ROC曲线下面积为0.690[95%CI(0.568,0.812),P=0.009]。结论 24 h、昼间的BPV与颅内外动脉狭窄呈正相关,24 h BPV对颅内外动脉狭窄的发生有一定的预测价值。
[Abstract]:Objective to investigate the relationship between (BPV) and intracranial and extracranial artery stenosis in patients with essential hypertension and its predictive value. Methods A total of 80 patients with essential hypertension were selected from August 2013 to October 2015 in the people's Hospital of Peking University. 24 h ambulatory blood pressure monitoring (ABPM),) was performed on the patients. The standard deviation of blood pressure reading (SD) was used to represent the BPV value. CT angiography (CTA) and / or magnetic resonance angiography (MRA) were used to diagnose the degree of intracranial and extracranial artery stenosis. Spearman correlation analysis was used to investigate the relationship between BPV and intracranial and extracranial artery stenosis in patients with essential hypertension. The value of 24 h BPV in predicting intracranial and extracranial artery stenosis was evaluated by (ROC) curve. Results Spearman correlation analysis showed that there was a positive correlation between diurnal BPV and extracranial artery stenosis at 24 h (P0.05). The area under the ROC curve of 24 h systolic pressure SD for predicting intracranial and extracranial artery stenosis was 0.712 [95%CI (0.595 卤0.829)]. P0. 004]; The area under the ROC curve predicted by 24 h diastolic pressure (SD) for intracranial and extracranial artery stenosis was 0.690 [95%CI (0.568 卤0.812), P0. 009]. Conclusion 24 h BPV was positively correlated with extracranial artery stenosis, and 24 h BPV had a certain predictive value for the occurrence of intracranial and extracranial artery stenosis.
【作者单位】：北京大学人民医院;河南省人民医院;
【分类号】：R544.11

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