养血清癜汤治疗原发性免疫性血小板减少症临床疗效Meta分析

发布时间：2018-11-17 17:57

【摘要】：目的:系统性地对养血清癜汤结合西医方法治疗原发性免疫性血小板减少症产生的药效学进行评价。方法:在计算机上,运用文献检索的方式和文献追溯的方式,查找与本文论题相关的医学参考文献,检索的年限设定在1985~2016年之间,检索的范围包括PubMed、EMbase、Wanfang data电子数据库等等。检索词:ITP、原发性免疫性血小板减少症、养血清癜汤。此外,利用百度、搜狗、360等搜索引擎在Web上查找与内容相关的文献,并查找已被纳入本论文的参考文献,以补充可能遗漏的研究文献。在RevMan 5.2软件中按照Meta分析流程,选择方法计算合并的RR值及95%可信区间,并进行敏感性分析和发表偏倚的估计。结果:本文共纳入7个研究,合计474例ITP患者,Meta分析结果显示:养血清癫汤治疗组的总有效率较单纯西医治疗的对照组优势更明显[RR=1.23,95%CI可信区间为(1.17,1.29),P0.01],漏斗图图形显示发表性偏倚较小。同时,对ITP患者外周血小板计数以及产生血小板型巨核细胞的数值也有较好的提升作用,而且,远期疗效十分明显,不良反应也相对较少。结论:通过与对照剂做比较,养血清癜汤结合西医治疗ITP患者具有较高的有效率和良好的耐受性,且不良反应轻微。可以作为临床治疗ITP患者的一个选择。
[Abstract]:Objective: to systematically evaluate the pharmacodynamics of Yangxue Schonlein purpura decoction combined with western medicine in the treatment of idiopathic immune thrombocytopenia. Methods: by using the method of literature retrieval and the way of literature tracing, the medical references related to the topic of this paper were searched on the computer. The period of retrieval was set between 1985 and 2016, and the range of retrieval included PubMed,EMbase,. Wanfang data electronic database and so on. Keywords: ITP, primary immune thrombocytopenia, nourishing serum purpura decoction. In addition, Baidu, Sogou, 360 and other search engines are used to search the content related documents on Web, and search the references that have been included in this paper to supplement the research literature that may be missing. According to the flow chart of Meta analysis in RevMan 5.2 software, the combined RR value and 95% confidence interval were calculated by selecting the method, and the sensitivity analysis and publication bias estimation were carried out. Results: the results of Meta analysis showed that the total effective rate of the treatment group was significantly higher than that of the control group treated with western medicine alone [RR=1.23,95%CI confidence interval was (1.17 卤1.29)]. P 0.01), the funnel graph showed less published bias. At the same time, the peripheral platelet count and the number of platelet-type megakaryocytes produced in patients with ITP were also improved, and the long-term effect was very obvious, and the adverse reactions were relatively small. Conclusion: compared with the control group, Yangxue-Schonlein purpura decoction combined with western medicine has a high effective rate and good tolerance, and the adverse reaction is slight. It can be used as an option for clinical treatment of ITP patients.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R558.2

【参考文献】