CTRP9基因多态性与冠心病的相关性

发布时间：2018-11-19 19:29

【摘要】：目的探讨广东地区汉族人群CTRP9基因多态性与冠心病遗传易感的相关性。方法入选冠心病患者548例和对照个体862例,利用聚合酶链式反应-连接酶检测反应(PCR-LDR)技术检测CTRP9基因的两个多态性位点rs6583、rs9553238的基因型,并采用Logistic回归分析两个多态位点和冠心病的易感性。结果 rs6583和rs9553238的等位基因、基因型频率在广东地区汉族人群的冠心病组和对照组分布中均无统计学差异(P0.05),构建的显性模型、隐性模型、加性模型在冠心病组和对照组中也无统计学差异(P0.05);CTRP9基因单体型(rs6583-rs9553238)在这两组中仍未发现有统计学差异(P0.05)。结论 CTRP9基因rs6583和rs9553238多态位点与广东地区汉族人群的冠心病遗传易感无显著相关性。
[Abstract]:Objective to investigate the association between CTRP9 gene polymorphism and genetic susceptibility to coronary heart disease (CHD) in Guangdong Han population. Methods A total of 548 patients with coronary heart disease and 862 controls were enrolled. Polymerase chain reaction-ligase assay (PCR-LDR) technique was used to detect the genotypes of rs6583,rs9553238 at two polymorphic sites of CTRP9 gene. Two polymorphic loci and susceptibility to coronary heart disease were analyzed by Logistic regression analysis. Results the alleles and genotype frequencies of rs6583 and rs9553238 were not significantly different in CHD group and control group in Guangdong Han population (P0.05). The dominant model and recessive model were constructed. There was no significant difference in the additive model between the coronary heart disease group and the control group (P0.05). CTRP9 haplotype (rs6583-rs9553238) was not found in the two groups (P0.05). Conclusion there is no significant correlation between the polymorphism of rs6583 and rs9553238 of CTRP9 gene and the genetic susceptibility to coronary heart disease in Guangdong Han population.
【作者单位】：广东医科大学衰老研究所;广东医科大学广东省医学分子诊断重点实验室;广东医科大学生物化学与分子生物学研究所;
【基金】：国家自然科学基金(81370456) 广东省扬帆计划培养高层次人才项目(4YF16006G) 东莞市社会科技发展项目(2015108101015,2013108101057)
【分类号】：R541.4

【相似文献】