臭氧自血疗法辅助治疗男性原发性高血压病的疗效和安全性研究

发布时间：2018-11-28 14:24

【摘要】：目的观察评估臭氧自血疗法(O3-AHT)辅助治疗男性原发性高血压病的疗效和安全性。方法选取2014年1月—2015年1月在首都医科大学宣武医院就诊的男性原发性高血压病患者60例,采用随机数字表法分为试验组和对照组,各30例。对照组给予口服左旋氨氯地平,5 mg/次,1次/d。试验组在对照组基础上,给予O3-AHT(浓度为20 mg/L、1次/2 d、10次/疗程)辅助治疗。记录治疗前(T0)、首次疗程结束后3个月(T1)、二次疗程结束后3个月(T2)、三次疗程结束后3个月(T3)的收缩压(SBP)和心率(HR);记录T3的药物口服情况和满意度指数(PSI)评分等级;记录治疗期间不良反应发生情况。结果两组年龄、病程间差异无统计学意义(P0.05)。两组SBP间差异有统计学意义(P0.05),不同时间点SBP间差异有统计学意义(P0.05),治疗方法和时间在SBP上存在交互作用(P0.05)。两组HR间差异无统计学意义(P0.05),不同时间点HR间差异无统计学意义(P0.05);治疗方法和时间在HR上不存在交互作用(P0.05)。试验组药物口服情况和PSI评分等级均优于对照组,差异有统计学意义(P0.05)。两组患者均无一例出现严重低血压、心脑血管意外、溶血、过敏等不良反应。结论O3-AHT辅助治疗男性原发性高血压病的疗效确切,安全性高。
[Abstract]:Objective to evaluate the efficacy and safety of self-blood ozone therapy (O3-AHT) in the treatment of male essential hypertension. Methods 60 male patients with essential hypertension were selected from Xuanwu Hospital of Capital Medical University from January 2014 to January 2015. They were randomly divided into two groups: experimental group (n = 30) and control group (n = 30). The control group was given levamlodipine once a day for 5 mg/. The experimental group was treated with O3-AHT (20 mg/L,1 / 2 d 10 times a course of treatment) on the basis of the control group. Systolic blood pressure (SBP) and heart rate (HR);) were recorded before treatment (T0), 3 months after the end of the first course of treatment (T1), 3 months after the end of the second course of treatment (T2) and 3 months after the end of the third course of treatment (T3). Drug oral status and (PSI) score of satisfaction index were recorded. Adverse reactions were recorded during treatment. Results there was no significant difference in age and course of disease between the two groups (P0.05). The difference of SBP between the two groups was statistically significant (P0.05), the difference between SBP at different time points was statistically significant (P0.05), the treatment method and time had interaction on SBP (P0.05). There was no significant difference in HR between the two groups (P0.05), there was no significant difference in HR at different time points (P0.05); there was no interaction between treatment methods and time on HR (P0.05). The drug oral and PSI scores in the trial group were better than those in the control group (P0.05). No severe hypotension, cardiovascular accident, hemolysis, anaphylaxis were found in both groups. Conclusion O3-AHT is effective and safe in the treatment of male essential hypertension.
【作者单位】：首都医科大学宣武医院疼痛科;承德护理职业学院;
【基金】：北京市医院管理局临床医学发展专项经费资助项目(ZYLX201507)
【分类号】：R544.11

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