老年骨质疏松与颈动脉硬化的相关性研究

发布时间：2018-12-11 03:51

【摘要】：目的探讨研究老年骨质疏松与颈动脉硬化的相关性。方法将随机抽取的236名60岁以上的体检者作为研究对象,采用双能X线骨密度仪测定腰椎(L_(1-4))及股骨颈、Word’s三角、大转子的骨密度(bone mineral density,BMD)。采用高分辨率彩色超声探查颈动脉内中膜厚度(intima-media thickness,IMT)及斑块的情况。同时收集研究对象的基本资料,包括年龄、身高、体重、血钙、血脂等生化结果。将入选对象分为骨质疏松组和非骨质疏松组,颈动脉有斑块组和颈动脉无斑块组。结果在骨质疏松组(114例)中,存在内膜增厚94例(82.46%),粥样斑块73例(64.04%),与非骨质疏松组(122名)比较,骨质疏松组在颈动脉内中膜增厚(IMT≥0.9 mm)及粥样斑块的发生率上均明显升高(P0.05);IMT增厚及斑块形成与骨量逐渐减少呈正相关,IMT、年龄、体重指数(body mass index,BMI)与骨质疏松发生显著相关(P0.05);性别分组比较得出,女性骨质疏松患者在颈动脉斑块中的发病率明显高于男性和非骨质疏松患者,其对比差异具有统计学意义(P0.05)。结论老年骨质疏松与动脉硬化存在密切联系;骨质疏松人群较非骨质疏松人群更易发生动脉粥样硬化病变,且女性骨质疏松患者的颈动脉硬化患病率明显高于男性。
[Abstract]:Objective to study the correlation between senile osteoporosis and carotid atherosclerosis. Methods the bone mineral density (bone mineral density,BMD) of lumbar vertebrae (L1-4), femoral neck, Word's triangle and trochanter were measured by dual energy X-ray absorptiometry. Carotid intima media thickness (intima-media thickness,IMT) and plaque were examined by high resolution color ultrasound. At the same time, basic data were collected, including age, height, weight, blood calcium, blood lipid and other biochemical results. The subjects were divided into osteoporosis group and non-osteoporosis group, carotid plaque group and carotid artery without plaque group. Results there were 94 cases (82.46%) of intimal thickening and 73 cases (64.04%) of atherosclerotic plaques in the osteoporosis group (114 cases), which were compared with those in the non-osteoporosis group (122 cases). The incidence of carotid intima media thickening (IMT 鈮，

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