复方丹参注射液治疗慢性肺源性心脏病急性加重期疗效的Meta分析

发布时间：2018-12-23 19:25

【摘要】：目的系统评价复方丹参注射液治疗慢性肺源性心脏病(肺心病)急性加重期的疗效。方法检索Cochrane协作网数据库、Pub Med、医学文摘资料库(EMbase)、中国学术期刊网络出版总库(CNKI)、中国生物医学文献数据库(CBMdisc)、维普科技期刊数据库(VIP)和万方数据库,搜集复方丹参注射液治疗慢性肺心病急性加重期的随机对照试验(RCT),检索时限为1997年1月-2016年12月。由2位研究者独立筛选文献、提取资料,采用牛津评分系统(Jadad)评价纳入研究的质量,使用Rev Man 5.3软件进行Meta分析。结果共纳入17项研究,Meta分析结果显示,复方丹参注射液组治疗有效率[Z=7.49,P=0.00,^OR=2.39,95%CI(1.91,3.01)]、动脉氧分压[MD=1.96,95%CI(0.91,3.02),P=0.00]的提高程度均优于对照组;血浆粘度[MD=-0.10,95%CI(-0.18,-0.02),P=0.01]、动脉二氧化碳分压[MD=-0.97,95%CI(-1.27,-0.67),P=0.00]的降低程度均优于对照组;红细胞压积、血沉率复方丹参组与对照组间差异无统计学意义(P0.05)。结论复方丹参注射液治疗慢性肺心病急性加重期有较好疗效,但受限于现有研究的数量和质量,还需开展更高质量的大样本随机对照试验进一步证实。
[Abstract]:Objective to evaluate the therapeutic effect of compound salvia miltiorrhiza injection on acute exacerbation of chronic pulmonary heart disease (Cor pulmonale). Methods the database of Cochrane collaboration network, Pub Med, medical abstract database, (EMbase), database of Chinese academic journals, (CNKI), database of Chinese biomedical literature, (CBMdisc), Weip scientific journal database, (VIP) and Wanfang database, were searched. The (RCT), search time of compound Salvia miltiorrhiza injection in the treatment of acute exacerbation of chronic cor pulmonale was from January 1997 to December 2016. Two researchers independently sifted the literature and extracted the data. The quality of the study was evaluated by Oxford scoring system (Jadad). The Meta analysis was carried out with Rev Man 5.3 software. Results the results of Meta analysis showed that the effective rate of compound salvia miltiorrhiza injection group was 0.00,1.91 OR=2.39,95%CI (1.91 卤3.01), and the partial pressure of arterial oxygen [MD=1.96,95%CI (0.91 卤3.02)]. The improvement of P0.00] was better than that of the control group. Plasma viscosity [MD=-0.10,95%CI (-0.18 -0.02), P0. 01], arterial partial pressure of carbon dioxide [MD=-0.97,95%CI (-1.27 -0.67), P0. 00] were significantly lower than those of the control group. There was no significant difference in hematocrit and erythrocyte sedimentation rate between Danshen group and control group (P0.05). Conclusion compound salvia miltiorrhiza injection is effective in the treatment of chronic cor pulmonale in acute exacerbation, but limited by the quantity and quality of existing research, it needs to be further confirmed by large sample randomized controlled trial.
【作者单位】：南昌大学医学院第一临床医学院;
【分类号】：R541.5

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