心外膜脂肪厚度与冠心病复杂程度的相关性研究

发布时间：2019-01-06 10:55

【摘要】：目的探讨心外膜脂肪组织(Epicardial adipose tissue,EAT)厚度是否与冠状动脉病变Gensini评分、Syntax评分相关;并进一步评价其是否可作为预测严重的、复杂的冠状动脉狭窄的预测因素。方法将102名符合纳入标准的患者根据冠状动脉造影(coronary arteriography,CAG)结果分2组,正常冠脉组、冠心病病变组(≥1冠状动脉病变≥50%)。同期使用经胸超声心动图测量EAT厚度,并回顾CAG图像得出Gensini评分、Syntax评分。结果EAT厚度在冠脉正常组为3.89±0.2mm,冠心病病变组为6.19±1.19mm(P0.001)。结果显示EAT的厚度分别为5 mm、5-7mm和7 mm时,Gensini评分分别为:7.21±7.73,37.80±29.55和62.77±27.26;Syntax评分分别为:7.13±7.70,19.71±7.27和24.95±4.31。EAT的厚度与Gensini评分(r=0.621;P0.001)、Syntax评分(r=0.689;P0.001)正相关,与冠心病病变复杂程度正相关。ROC曲线显示,EAT厚度提示冠脉病变较高复杂程度的最佳诊断界限值为5.55mm(曲线下面积0.834,95%可信区间(CI),0.755—0.913;P0.001)。敏感性为90.9%,特异性为67.7%。结论心外膜脂肪组织厚度与冠状动脉狭窄的复杂程度评分,Gensini评分、Syntax评分相关,它可作为预测冠状动脉狭窄复杂病变的预测因素。
[Abstract]:Objective to investigate whether the thickness of epicardial adipose tissue (Epicardial adipose tissue,EAT) is correlated with the Gensini score and Syntax score of coronary artery disease, and to evaluate whether the thickness of epicardial adipose tissue can be used as a predictor of severe and complicated coronary artery stenosis. Methods according to the results of coronary angiography (coronary arteriography,CAG), 102 patients with coronary artery disease were divided into two groups: normal coronary artery group and coronary artery disease group (鈮，

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