罗布麻茶水提物对自发性高血压大鼠血压的调节作用

发布时间：2019-01-17 19:29

【摘要】：目的:研究罗布麻茶水提物对自发性高血压大鼠(Spontaneous hypertension rat,SHR)血压的调节规律以及降压时相的出现与其它生理指标变化的关系。方法:以SHR为实验动物,每天灌胃1次受试物,每周1次采用尾套法连续测试灌胃后8~10 h内的收缩压及心率,6周后测试降压时相的体质量、尿量及尿钠、尿钾的分泌以及血脂含量。结果:与阴性对照组相比,灌胃罗布麻茶水提物后SHR收缩压(SBP)先升高后下降,这种现象在连续灌胃3周后明显,而心率无显著的规律性变化;稳定的降压时相(8 h左右)在连续灌胃3周后出现,最大降幅达16 mm Hg;降压时相SHR的体质量及血脂无显著变化(P≥0.05),尿量及尿钠、尿钾的分泌显著增加(P0.05)。结论 :罗布麻茶水提物对SHR收缩压具有先升高后下降的双向调节作用,然而起效慢,降压时相的出现可能与其利尿及利钠、利钾作用有关。
[Abstract]:Aim: to study the regulation of (Spontaneous hypertension rat,SHR blood pressure and the relationship between the appearance of hypotensive phase and the changes of other physiological indexes. Methods: the systolic blood pressure (SBP) and heart rate (HR) of SHR were measured once a day, once a week, and 6 weeks later, the volume of body mass, urine volume and urine sodium were measured. Urinary potassium secretion and blood lipid content. Results: compared with the negative control group, SHR systolic pressure (SBP) increased at first and then decreased after the tea extract of Apocynum gavicum. This phenomenon was obvious after 3 weeks of continuous gastric perfusion, but there was no significant regular change of heart rate. Stable hypotensive phase (about 8 h) appeared after 3 weeks of continuous gastric perfusion, with a maximum decrease of 16 mm Hg;. There was no significant change in body mass and blood lipid of SHR at hypotensive phase (P > 0. 05), but urine volume, urine sodium and urinary potassium secretion were significantly increased (P0.05). Conclusion: Apocynum tea extract has a bidirectional regulating effect on systolic blood pressure of SHR, but its effect is slow. The phase of depressor phase may be related to its diuretic, natriuretic and potassium effects.
【作者单位】：中国农业大学食品科学与营养工程学院;渤海大学食品科学与工程学院;食品营养与人类健康高精尖创新中心食品科学与营养工程学院中国农业大学;
【基金】：北京市科技计划项目(D121100003112004;D121100003112001)
【分类号】：R544.1

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