血清γ谷氨酰转移酶水平与急性心力衰竭患者预后的相关性研究

发布时间：2019-01-25 07:41

【摘要】：目的：评价血清γ谷氨酰转移酶(Serum gamma glutamine transferase,GGT)水平与急性心力衰竭(acute heart failure, AHF)患者预后的相关性。方法：选取2012年9月至2013年1月期间于我院心脏中心住院的急性左心室收缩功能衰竭患者188例(男性78例,女性110例)临床资料进行回顾性分析,根据患者预后死亡或存活分为死亡组及存活组,其中死亡组36例,男14例,女22例,平均年龄(67.28±11.04)岁,存活组152例,男64例,女88例,平均年龄(63.95±12.42)岁,分析两组患者的基本临床资料及院内死亡率。结果：两组间射血分数、心房纤颤、民族、高血压、高密度脂蛋白、低密度脂蛋白、血尿素氮、血肌酐、肌酸激酶、肌酸激酶同工酶、总胆汁酸、心房脑钠肽均有显著差异。死亡组与存活组比较,两组患者的血清γ谷氨酰转移酶分别为39.24±5.90和31.03±10.22,有显著差异；两组间性别、年龄、空腹血糖、脂蛋白(a)、总蛋白、甘油三酯、总胆固醇、尿酸、糖尿病、心力衰竭分级、药物应用均无明显差异；根据血清γ谷氨酰转移酶水平患者也分为两组,高血清γ谷氨酰转移酶组与低血清γ谷氨酰转移酶组死亡率比例为(15.3%vs4.6%)。Logistic回归分析显示血清γ谷氨酰转移酶为急性心力衰竭的危险因素P0.05。用ROC曲线对评价血清γ谷氨酰转移酶对于急性心力衰竭死亡死亡的诊断价值,敏感度78.9%,特异度66.7%,cutoff值35.5 U/L,曲线下的面积为0.759,95%的置信区间0.662-0.859,P0.05。结论：血清γ谷氨酰转移酶水平与急性心力衰竭患者预后有相关性,具有一定的临床应用价值。
[Abstract]:Objective: to evaluate the correlation between serum 纬-glutamyltransferase (Serum gamma glutamine transferase,GGT) level and prognosis of patients with acute heart failure (acute heart failure, AHF). Methods: the clinical data of 188 patients with acute left ventricular systolic failure (78 males and 110 females) hospitalized in our heart center from September 2012 to January 2013 were retrospectively analyzed. According to the prognosis, the patients were divided into death group (n = 36) and survival group (n = 36, male 14, female = 22, mean age: (67.28 卤11.04) years), survival group (n = 152), male (64), female (88), mean age (63.95 卤12.42). The basic clinical data and hospital mortality of the two groups were analyzed. Results: there were significant differences in ejection fraction, atrial fibrillation, nationality, hypertension, high density lipoprotein, low density lipoprotein, blood urea nitrogen, serum creatinine, creatine kinase isoenzyme, total bile acid and atrial brain natriuretic peptide between the two groups. The serum levels of 纬 -glutamyltransferase were 39.24 卤5.90 and 31.03 卤10.22 in the death group and the survival group, respectively. There were no significant differences in sex, age, fasting blood glucose, lipoprotein (a), total protein, triglyceride, total cholesterol, uric acid, diabetes mellitus, heart failure grade and drug use between the two groups. According to the level of serum 纬 -glutamyl transferase, patients were also divided into two groups. The mortality ratio of high serum 纬 -glutamyltransferase group and low serum 纬 -glutamyltransferase group was 15.3vs4.6%). Logistic regression analysis showed that serum 纬 -glutamyltransferase was a risk factor for acute heart failure (P0.05). The ROC curve was used to evaluate the diagnostic value of serum 纬 -glutamyltransferase in the death of acute heart failure. The sensitivity was 78.9 and the specificity was 66.7U / L, which was 35.5 UL / L, respectively. The area under the curve is 0.759V 95% confidence interval 0.662-0.859g P0.05. Conclusion: the level of serum 纬-glutamyl transferase is correlated with the prognosis of patients with acute heart failure.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R541.6
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本文编号：2414938