整合素α5和PDE4D相互作用调节内皮细胞的炎症信号
发布时间：2019-03-23 16:08
【摘要】：正动脉粥样硬化是一种以脂代谢紊乱和炎症为主要表现的疾病,然而它也与内皮细胞外基质(extracellular matrix,ECM)的重塑和纤维连接蛋白(fibronectin)在层粘连蛋白(laminin)-胶原基底膜间的沉积密切相关。为了研究纤维连接蛋白如何调节动脉中的炎症,Yun等将纤维连接蛋白受体整合素α5的胞质尾区替换为胶原/层粘连蛋白受体整合素α2的胞质尾区。这一
[Abstract]:Positive atherosclerosis is a disease characterized mainly by lipid metabolism disorder and inflammation. However, it is also associated with endothelial extracellular matrix (extracellular matrix,). The remodeling of ECM is closely related to the deposition of fibronectin (fibronectin) between laminin (laminin)-collagen basement membrane. In order to study how fibronectin regulates inflammation in arteries, Yun and others replaced the cytoplasmic tail region of fibronectin receptor integrin 伪 5 with that of collagen / laminin receptor integrin 伪 2. This one
【分类号】：R543.5
，
本文编号：2446001
[Abstract]:Positive atherosclerosis is a disease characterized mainly by lipid metabolism disorder and inflammation. However, it is also associated with endothelial extracellular matrix (extracellular matrix,). The remodeling of ECM is closely related to the deposition of fibronectin (fibronectin) between laminin (laminin)-collagen basement membrane. In order to study how fibronectin regulates inflammation in arteries, Yun and others replaced the cytoplasmic tail region of fibronectin receptor integrin 伪 5 with that of collagen / laminin receptor integrin 伪 2. This one
【分类号】：R543.5
，
本文编号：2446001
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