脉搏波速度与射血分数保留性心力衰竭舒张功能的相关性研究

发布时间：2019-03-30 20:39

【摘要】：目的：探讨脉搏波速度与射血分数保留性心力衰竭舒张功能的关系。方法：选择射血分数保留性心力衰竭患者40例与同期体检的健康人群52例分别作为病例组与对照组,所有人均进行脉搏波速度检测并行超声心动图检查进行心脏结构和功能的测定,同时采集氨基末端脑钠肽前体(NT-proBNP)、空腹血糖(FPG)等实验室检查指标。比较两组间各指标是否有统计学差异,并进行各指标间相关性分析。结果：与对照组相比,心衰组颈-股动脉脉搏波速度(C-FPWV)、收缩压、舒张压、平均动脉压、脉压差,血尿酸及空腹血糖均升高；C-FPWV与年龄、烟酒史、收缩压、平均动脉压、脉压差及空腹血糖相关,与心功能指标左室质量指数-线性法测量(LVMi-L)、左房容积指数(LAVi)、左房内经指数(LADi)、二尖瓣舒张早期峰值速度与二尖瓣环运动速度比值(侧壁、室间隔及平均值)(E/E'L, E/E'S, M-E/E')及以10为底数经对数转换后的log NT-proBNP均相关。并与log NT-proBNP独立相关。结论：脉搏波速度与射血分数保留性心力衰竭舒张功能有明显相关性。
[Abstract]:Objective: to investigate the relationship between pulse wave velocity and diastolic function in heart failure with ejection fraction retention. Methods: 40 patients with heart failure with ejection fraction retention and 52 healthy people who had physical examination at the same time were selected as the case group and the control group, respectively. Pulse wave velocity and cardiac structure and function were measured by echocardiography. Laboratory parameters such as amino-terminal brain natriuretic peptide precursor (NT-proBNP) fasting blood glucose (FPG) and so on were collected at the same time. Whether there was statistical difference between the two groups was compared, and the correlation analysis was carried out between the two groups. Results: compared with the control group, the carotid-femoral artery pulse wave velocity (C-FPWV), systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse pressure difference, serum uric acid and fasting blood glucose increased in the heart failure group. C-FPWV was correlated with age, history of smoking and alcohol, systolic blood pressure, mean arterial pressure, pulse pressure difference and fasting blood glucose. Left ventricular mass index (LVMi-L), left atrial volume index (LAVi),) and left atrial meridian index (LADi),) were measured with left ventricular mass index (LVMi-L) and left atrial volume index (LVVI). The ratio of mitral annulus velocity (lateral wall, interventricular septum and mean value) (E / L, E / E', M / E') and the logarithmic conversion (log NT-proBNP) at the base of 10 were all correlated with the peak velocity of mitral valve early diastolic velocity (PSV) in patients with mitral annulus motion (lateral wall, ventricular septum and mean value). And it is independent of log NT-proBNP. Conclusion: there is a significant correlation between pulse wave velocity and diastolic function in heart failure with ejection fraction retention.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R541.6

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