冠状动脉病变严重程度与血清脂蛋白磷脂酶及脂联素水平的相关性

发布时间：2019-04-09 16:11

【摘要】：目的探讨血清脂蛋白磷脂酶A2及脂联素水平与冠状动脉病变严重程度的关系。方法选取冠心病患者106例,根据Gensini积分分成3个实验组:积分30分(31例)、30~90分(38例)、90分(37例);同期体检健康老年人30例为对照组。4组成员均于清晨空腹采血,1 500 r/min离心,10 min,留血清待测。采用酶联免疫吸附法和实时荧光定量法检测血清脂蛋白磷脂酶A2及脂联素水平,进行积分与各种检验指标的相关分析。结果与对照组比较,3个实验组血清脂蛋白磷脂酶A2水平均明显升高、脂联素水平均明显降低(P0.05),且有随积分的增高血清脂蛋白磷脂酶A2水平升高、脂联素水平降低的趋势(P0.05)。冠状动脉病变严重程度与血清脂蛋白磷脂酶A2水平呈正相关(r=1.318,P0.05)、与血清脂联素水平呈负相关(r=-0.969,P0.05)。结论血浆脂蛋白磷脂酶A2和脂联素联合检测,可判断冠心病患者冠脉病变严重程度。
[Abstract]:Objective to investigate the relationship between serum lipoprotein phospholipase A 2 and adiponectin levels and severity of coronary artery disease. Methods 106 patients with coronary heart disease were divided into 3 groups according to Gensini score: 30 points (31 cases), 30 points (38 cases) and 90 points (37 cases). At the same time, 30 healthy elderly were taken as the control group. All the 4 groups were taken fasting blood in the morning, centrifuged at 1,500 r/min, and kept serum for 10 min, to be tested. Serum lipoprotein phospholipase A _ 2 and adiponectin levels were measured by enzyme-linked immunosorbent assay (Elisa) and real-time fluorescence quantitative method. Results compared with the control group, the levels of serum lipoprotein phospholipase A _ 2 and adiponectin were significantly increased in the three experimental groups (P 0.05), and the serum lipoprotein phospholipase A _ 2 level was increased with the increase of the integrals, and the level of lipoprotein phospholipase A _ 2 in serum was significantly higher than that in the control group. Adiponectin level decreased trend (P0.05). The severity of coronary artery disease was positively correlated with serum lipoprotein phospholipase A 2 level (r = 1.318, P0.05), and negatively correlated with serum adiponectin level (r = 0.969, P0.05). Conclusion the combined detection of lipoprotein phospholipase A 2 and adiponectin can judge the severity of coronary artery disease in patients with coronary heart disease.
【作者单位】：泰州市人民医院;
【分类号】：R541.4

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