累积高血压暴露与臂踝脉搏波传导速度的关系

发布时间：2019-04-21 12:50

【摘要】：目的探讨累积高血压暴露和臂踝动脉脉搏波传导速度的关联。方法在参与开滦集团第1次健康体检(2006年~2007年)的101510名开滦职工中,按照分层随机抽样标准方式抽取观察对象,其中符合入选标准者5440人,对上述人群进行了第4次体检(2012年~2013年),并测量了该人群的臂踝动脉脉搏波传导速度(ba PWV),最后共有3676人纳入统计分析。将人群按照高血压暴露时间分为累积高血压暴露0年、2年、4年、6年、8年共5组,采用了Logistic回归方法分析了不同累积高血压暴露组与ba PWV≥1400cm/s的关联。结果在3676名观察对象中,平均年龄为55.70±9.84岁。其中,男性2012人(54.7%),女性1664人(45.3%)。随着高血压累积暴露时间的延长,ba PWV均值和ba PWV≥1400cm/s的比例均逐渐增高(均P0.05)。在Logistic回归分析中,校正了相关因素后,结果提示,与累积高血压暴露0年组相比,暴露2年组、4年组、6年组、8年组均是发生ba PWV≥1400cm/s的危险因素,OR值(95%CI)分别为1.76(1.38~2.25)、2.06(1.54~2.77)、3.14(2.18~4.53)、3.05(1.96~4.74);在比较回归方程的拟合情况时发现累积高血压暴露与ba PWV的关联强于基线高血压暴露。结论长时间的累积高血压暴露是ba PWV≥1400cm/s的危险因素;累积高血压暴露与ba PWV的关联强于基线高血压暴露。
[Abstract]:Objective to investigate the relationship between cumulative hypertension exposure and brachial and malleolus artery pulse wave velocity (PWV). Methods 101510 Kailuan staff and workers who participated in the first health check-up of Kailuan Group (2006-2007) were selected according to the stratified random sampling standard, of which 5440 met the selection criteria. The fourth physical examination (2012-2013) was carried out and the brachial-ankle artery pulse wave velocity (ba PWV),) of the population was measured. A total of 3676 people were included in the statistical analysis. According to the time of hypertension exposure, the population was divided into 5 groups: accumulative hypertension exposure for 10 years, 2 years, 4 years, 6 years and 8 years. Logistic regression method was used to analyze the association between different accumulative hypertension exposure groups and ba PWV 鈮，

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