解毒活血方对经皮冠状动脉介入术患者围术期心肌损伤的影响

发布时间：2019-04-27 19:22

【摘要】：目的观察解毒活血配方颗粒冲服对经皮冠状动脉介入术(PCI)患者的围术期心肌损伤的影响。方法 160例接受PCI术的心绞痛患者随机分为解毒活血组(n=84)和对照组(n=76),解毒活血组给予常规治疗同时术前第7天给予解毒活血配方颗粒冲服,每日1剂。对照组给予基础药物治疗。测定PCI术前及术后12 h、24 h的血清肌酸激酶同工酶(CK-MB)和肌钙蛋白I(cTn I)浓度。结果解毒活血组PCI术后12 h、24 h cTn I和CK-MB水平均显著低于对照组(P=0.0038,P=0.027 6;P=0.001 2,P=0.002 7)。解毒活血组患者术后cTn I和CK-MB升高大于正常值3倍者构成比均显著低于对照组(P=0.008 2,P=0.007 6)。结论术前给予解毒活血配方颗粒对于PCI围手术期病人的心肌损伤具有一定的保护作用。
[Abstract]:Objective to observe the effect of jiedu Huoxue recipe on perioperative myocardial injury in (PCI) patients undergoing percutaneous coronary intervention (PCI). Methods 160 patients with angina pectoris undergoing PCI were randomly divided into two groups: detoxification group (n = 84) and control group (n = 76). The patients in group A were treated with routine therapy and were given jiedu Huoxue formula granules once a day on the 7th day before operation. The control group was treated with basic drugs. Serum creatine kinase isoenzyme (CK-MB) and troponin I (cTn I) were measured before and 12 h and 24 h after PCI. Results the levels of 24 h cTn I and CK-MB in the detoxification and promoting blood circulation group at 12 h after PCI were significantly lower than those in the control group (P = 0.0038, P = 0.027 6, P = 0.001 2, P = 0.002 7). The ratio of cTn I and CK-MB increased more than 3 times of the normal value in the detoxification and activating blood circulation group after operation was significantly lower than that in the control group (P = 0.008 2, P < 0.007 6). Conclusion pre-operative administration of jiedu Huoxue formula granules has certain protective effect on myocardial injury in patients with PCI during perioperative period.
【作者单位】：南京中医药大学附属中西医结合医院心血管科;江苏省中医药研究院;南京中医药大学;
【基金】：国家自然科学基金资助项目(No.81403386) 江苏省自然科学基金资助项目(No.BK20161078) 中国中医科学院江苏分院资助项目(No.JSBY1316)~~
【分类号】：R541.4

【相似文献】