慢性心衰患者心功能与外周血清CA125、CysC及心率变异性的相关分析

发布时间：2019-05-27 14:48

【摘要】：目的:测定慢性心衰(CHF)患者血清CA125、CysC的浓度,联合B型钠尿肽(BNP)、心脏超声数据,研究慢性心衰患者心功能与CA125、Cys C的关系,在此基础上研究此类患者心率变异性的改变,以期为此病的早发现和病情监测提供科学依据。方法:收集70例CHF患者资料,遵循NYHA标准分I/II、III、IV三组。并选40例健康人为健康组。采集所有入组者的心率变异性数值及血液标本,测CA125、CysC、BNP值,比较各组CA125、Cys C水平及心率变异性差异;分析所有心衰患者血清CA125、Cys C与BNP、LVEF、LVEDd的相关性。1、CHF患者血清CA125值高于健康者,并随心衰加重而逐步升高。与外周血清BNP水平呈正相关,与LVEF呈负相关,与LVEDd呈正相关。2、CHF患者血清Cys C值高于健康者,并随心衰加重而逐步升高。与外周血清BNP水平呈正相关,与LVEF呈负相关,与LVEDd呈正相关。3、CHF患者SDANN较健康者有明显降低,且随心衰加重而逐步降低;NYHAIII组、IV组患者SDNN较健康者明显降低,且随心衰加重而逐步降低。结论:CHF患者心律变异性较健康人明显降低,并随心衰加重而降低;外周血清CA125、CysC高于健康人,并随心衰加重而升高。
[Abstract]:Objective: to determine the concentration of serum CA125,CysC in patients with chronic heart failure (CHF) and to study the relationship between cardiac function and CA125,CysC in patients with chronic heart failure (CRF) combined with B-type natriuretic peptide (BNP), cardiac ultrasound data. On this basis, the changes of heart rate variability (HRV) in these patients were studied in order to provide scientific basis for the early detection and monitoring of the disease. Methods: the data of 70 patients with CHF were collected and divided into three groups according to NYHA standard: I 鈮，

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