长春瑞滨在输液性静脉炎小鼠模型建立中的作用及干预措施

发布时间：2019-06-13 06:26

【摘要】：目的探讨长春瑞滨在输液性静脉炎小鼠模型建立中的作用及干预措施。方法选取健康成年小鼠,分别应用不同给药剂量、给药浓度以及给药速度,观察静脉炎发生情况,并应用西咪替丁等不同的H2受体阻断剂进行干预。结果长春瑞滨(VIN)给药浓度以及注射速度不变的情况下,注射剂量越多,小鼠静脉炎的发生率更高并且更加严重(P0.05);给药浓度下降后增加了注射难度并提高了小鼠死亡率(P0.05);给药速度越快,小鼠静脉炎发生风险越高(P0.05);预先应用西咪替丁可以显著降低小鼠静脉炎的发生率(P0.05)。结论制备动物模型能够为改进VIN用药方法提供重要参考,并进一步探索干预输液性静脉炎的药物治疗措施。
[Abstract]:Objective to investigate the role and intervention of vinorelabine in the establishment of infusion phlebitis in mice. Methods healthy adult mice were treated with different dosage, concentration and speed of administration, and the occurrence of phlebitis was observed, and cimetidine and other different H2 receptor blockers were used for intervention. Results the higher the dose of vinorelbin (VIN) was, the higher and more serious the incidence of phlebitis in mice was (P 0.05). The decrease of administration concentration increased the difficulty of injection and the mortality of mice (P 0.05). The faster the administration rate, the higher the risk of phlebitis in mice (P 0.05), the higher the risk of phlebitis in mice (P 0.05), the higher the risk of phlebitis in mice (P 0.05), and the higher the risk of phlebitis in mice (P 0.05). Cimetidine could significantly reduce the incidence of phlebitis in mice (P 0.05). Conclusion the establishment of animal model can provide an important reference for improving the drug use method of VIN and further explore the drug treatment measures for intervention of infusion phlebitis.
【作者单位】：河南中医药大学第二附属医院(河南省中医院);河南省胸科医院;
【基金】：国家自然科学基金项目资助(No.81573919)
【分类号】：R-332;R543.6

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