微量白蛋白尿与心血管疾病
发布时间：2019-06-14 22:45
【摘要】：微量白蛋白尿(microalbuminuria,MAU)的出现不仅提示肾脏血管内皮受损,还可作为全身血管内皮受损的信号,是血管内皮功能障碍及血管炎症反应的早期预测因子。微量白蛋白尿在心血管疾病中,与心血管危险因素及心血管疾病关系密切,对动脉粥样硬化、冠心病、高血压、心力衰竭的病情评估及预后有重要的价值。但其是如何与心血管疾病有关的,目前尚未阐明,仍需要深入的基础研究。对于如何减少蛋白尿方面,目前在实际医疗工作中应用药物主要有四种:血管紧张素转换酶抑制剂、血管紧张素II受体拮抗剂、肾素抑制剂、醛固酮受体拮抗剂。但是否可通过减低蛋白尿来明显延缓心血管疾病的进展和改善患者预后,为心血管疾病的预防与治疗带来新的思路,仍需要更多的大数据样本及高质量的临床试验来证实。
[Abstract]:The appearance of microalbuminuria (microalbuminuria,MAU) not only suggests that renal vascular endothelial damage, but also can be used as a signal of systemic vascular endothelial damage, and is an early predictor of vascular endothelial dysfunction and vascular inflammation. Microalbuminuria is closely related to cardiovascular risk factors and cardiovascular diseases in cardiovascular diseases. It is of great value in the evaluation and prognosis of atherosclerosis, coronary heart disease, hypertension and heart failure. However, how it is related to cardiovascular disease has not yet been clarified, and further basic research is still needed. At present, there are four kinds of drugs used in practical medical work: angiotensin converting enzyme inhibitor, angiotensin II receptor antagonist, renin inhibitor and aldosterone receptor antagonist. However, whether we can significantly delay the progress of cardiovascular disease and improve the prognosis of patients by reducing albuminuria, and bring new ideas for the prevention and treatment of cardiovascular disease, more big data samples and high quality clinical trials are still needed to confirm it.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R54
本文编号：2499756
[Abstract]:The appearance of microalbuminuria (microalbuminuria,MAU) not only suggests that renal vascular endothelial damage, but also can be used as a signal of systemic vascular endothelial damage, and is an early predictor of vascular endothelial dysfunction and vascular inflammation. Microalbuminuria is closely related to cardiovascular risk factors and cardiovascular diseases in cardiovascular diseases. It is of great value in the evaluation and prognosis of atherosclerosis, coronary heart disease, hypertension and heart failure. However, how it is related to cardiovascular disease has not yet been clarified, and further basic research is still needed. At present, there are four kinds of drugs used in practical medical work: angiotensin converting enzyme inhibitor, angiotensin II receptor antagonist, renin inhibitor and aldosterone receptor antagonist. However, whether we can significantly delay the progress of cardiovascular disease and improve the prognosis of patients by reducing albuminuria, and bring new ideas for the prevention and treatment of cardiovascular disease, more big data samples and high quality clinical trials are still needed to confirm it.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R54
【参考文献】
相关期刊论文 前10条
1 那开宪;;应重视醛固酮受体拮抗剂在心血管疾病中的应用[J];中国临床医生杂志;2016年11期
2 吴法令;;31例急性心肌梗死病人再灌注后微量白蛋白尿与心功能变化的临床研究[J];中西医结合心脑血管病杂志;2016年14期
3 陈思梅;;探讨尿微量白蛋白水平与慢性心力衰竭患者心功能的关系[J];中国医学创新;2016年16期
4 安得英;高生云;吴成斌;黄海英;;高血压病患者血压变异性与尿微量白蛋白的关系研究[J];疾病监测与控制;2016年05期
5 赵汉君;葛智儒;杜安通;王璐;;尿微量白蛋白/尿肌酐比值与慢性心力衰竭的关系分析[J];中国医药导刊;2016年03期
6 张世阳;赵旭兰;梁芳;范亚坤;杨磊;吕新湖;;老年急性冠状动脉综合征冠状动脉支架内再狭窄与非再狭窄患者脂蛋白a、尿微量白蛋白分析[J];河北医科大学学报;2016年02期
7 王晓燕;宋春丽;籍振国;刘红彬;刘志红;;尿微量白蛋白水平对急性冠脉综合征介入治疗患者的预后评价作用[J];山东医药;2016年05期
8 吴建军;周期兴;袁国忠;周fE;;尿微量白蛋白检测在高血压性脑出血患者早期肾损害中的诊断价值[J];中国当代医药;2015年35期
9 郑智非;陈杰;;原发性高血压患者微量白蛋白尿与心室肥厚的关系[J];广东医学院学报;2015年05期
10 李晓红;杨明;韩凌;陈欣;陈萍;胡文泽;;微量白蛋白尿与冠状动脉病变相关性探讨[J];武警医学;2015年01期
，本文编号：2499756
本文链接：https://www.wllwen.com/yixuelunwen/xxg/2499756.html
最近更新
教材专著
