低剂量替格瑞洛对急性冠脉综合征患者血小板聚集率及出血的影响

发布时间：2019-06-25 19:20

【摘要】：目的观察低剂量替格瑞洛对急性冠脉综合征患者血小板聚集率及出血的影响。方法选取急性冠脉综合征患者584例,其中替格瑞洛标准剂量组(A组,替格瑞洛90 mg/次,2次/d)450例、替格瑞洛低剂量组(B组,替格瑞洛45 mg/次,2次/d)26例和氯吡格雷标准剂量组(C组,氯吡格雷75 mg/次,1次/d)108例。三组临床资料比较均无统计学差异(P均0.05)。治疗7 d后检测三组患者血小板聚集率(PAG),观察患者病情变化以及主要心血管事件、出血发生情况。结果 A、B、C组PAG分别为(2.91±2.022、3.06±1.843、5.46±3.401)Ω,A、B组PAG差异无统计学意义(P0.05),A组、B组PAG均低于C组(P均0.05);A、B、C组出血率分别为11.56%、7.69%、10.19%,三组出血率差异无统计学意义(P0.05)。三组患者临床症状得到有效控制,均无主要心血管事件发生。结论对急性冠脉综合征患者替格瑞洛低剂量与标准剂量相比可以起到相同的抗血小板聚集作用,且不增加患者的出血风险率。
[Abstract]:Objective to observe the effect of low dose tigrilol on platelet aggregation rate and bleeding in patients with acute coronary syndrome. Methods 584 patients with acute coronary syndrome were selected, including tigrilol standard dose group (group A, 90 mg/ times, twice a day), tegrilol low dose group (group B, 45 mg/ times, twice a day) and clopidogrel standard dose group (group C, clopidogrel 75 mg/, once a day). There was no significant difference in clinical data among the three groups (P 0.05). After 7 days of treatment, the platelet aggregation rate of the three groups was measured by (PAG), to observe the changes of the condition, the main cardiovascular events and the occurrence of bleeding. Results in group A, the PAG of group C was (2.91 卤2.022), 3.06 卤1.843 and 5.46 卤3.401, respectively, while there was no significant difference in PAG between group B and group B (P 0.05), while the bleeding rate of group B was 11.56%, 7.69%, 10.19%, and there was no significant difference among the three groups (P 0.05). The clinical symptoms of the three groups were effectively controlled and no major cardiovascular events occurred. Conclusion compared with the standard dose, the low dose of tegrilol can play the same antiplatelet aggregation effect in patients with acute coronary syndrome, and does not increase the risk of bleeding.
【作者单位】：山东省交通医院;
【分类号】：R541.4

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