福辛普利联合叶酸片治疗老年H型高血压的疗效观察

发布时间：2019-07-04 11:02

【摘要】：将150例H型高血压患者随机分成3组,均给予福辛普利10mg/d,对照组不给予叶酸片,叶酸治疗A组给予叶酸0.8mg/d,叶酸治疗B组给予叶酸5mg/d,用药1年后三组血压均显著降低,未见明显差异。叶酸片与福辛普利联合降压,未见到叶酸有协同降压的作用。叶酸片能显著降低血Hcy水平,但与剂量无明显相关性。服用叶酸1年未见脑梗死的发病率有下降趋势。目前外源性补充叶酸成为治疗H型高血压的一种辅助方法,但叶酸补充剂量的大小及疗程还未达成共识。本研究旨在观察福辛普利联合不同剂量叶酸对老年H型高血压的疗效。
[Abstract]:150 patients with type H hypertension were randomly divided into three groups, all of them were given fosinopril 10 mg / d, the control group was not given folic acid tablets, folic acid treatment group A was treated with folic acid 0.8 mg / d, folic acid treatment group B was given folic acid 5 mg / d, and the blood pressure of the three groups was significantly decreased one year after treatment, and there was no significant difference between the three groups. Folic acid tablets combined with fosinopril had no synergistic antihypertensive effect. Folic acid tablets could significantly reduce the level of blood Hcy, but there was no significant correlation between folic acid tablets and dose. The incidence of cerebral infarction without folic acid for 1 year showed a downward trend. At present, exogenous folic acid supplementation has become an auxiliary method for the treatment of type H hypertension, but the dosage and course of folic acid supplementation have not yet reached a consensus. The purpose of this study was to observe the efficacy of fosinopril combined with different doses of folic acid in the treatment of H-type hypertension in the elderly.
【作者单位】：大连市老年病医院;大连市友谊医院;
【分类号】：R544.1

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