生化指标及动态血压检测对隐匿性高血压的临床诊断

发布时间：2019-07-17 10:00

【摘要】：为了探讨脂代谢、尿酸等生化指标及动态血压监测对隐匿性高血压诊断的价值,本研究分别选取来我院诊断的隐匿性高血压患者91例,真性高血压患者120例,正常人群100例为隐匿性高血压组、真性高血压组和对照组,考察各组脂代谢、尿酸生化指标及动态血压数据的临床特点。与对照组相比,真性高血压组患者的血清总胆固醇(serum total cholesterol,TC)、低密度脂蛋白(low density lipoprotein,LDL)、载脂蛋白B(apolipoprotein B,APOB)均显著增高,隐匿性高血压组患者LDL明显增高;真性高血压组所有动态血压参数均高于对照组;隐匿性高血压组患者的白天、夜间、24 h平均收缩压(systolic blood pressure,SBP)和夜间、24 h平均舒张压(diastolic blood pressure,DBP)均明显高于对照组;3组的尿酸水平无明显差异。Spearman直线相关分析显示,TC、HDL、APOB与动态血压数据显著相关。研究表明,脂代谢、尿酸生化指标及动态血压的联合检测能更准确地评估隐匿性高血压,为隐匿性高血压的诊断与心血管疾病的预防提供参考;同时提示我们,脂代谢异常的人群罹患高血压疾病的风险更大,需特别注意隐匿性高血压的早期筛查。
[Abstract]:In order to study the value of serum lipid metabolism, uric acid and other biochemical indexes and dynamic blood pressure monitoring on the diagnosis of occult hypertension, in this study,91 patients with occult hypertension and 120 patients with true hypertension were selected. The clinical characteristics of lipid metabolism, uric acid biochemical index and ambulatory blood pressure data were studied in the true hypertension group and the control group. Compared with the control group, the serum total cholesterol (TC), low density lipoprotein (LDL), and apolipoprotein B (APOB) in the patients with true hypertension were significantly higher, and the LDL in the patients with concealed hypertension was significantly higher. All the dynamic blood pressure parameters in the true hypertension group were higher than that in the control group. The mean systolic blood pressure (SBP) and night time and the mean diastolic blood pressure (DBP) of the patients with the occult hypertension group were significantly higher than those in the control group. There was no significant difference in the levels of uric acid in the group 3. The Spearman line-related analysis showed that TC, HDL, APOB were significantly related to ambulatory blood pressure data. The results indicated that the combined detection of lipid metabolism, the biochemical index of uric acid and the dynamic blood pressure can more accurately assess the occult hypertension, provide reference for the diagnosis of the occult hypertension and the prevention of cardiovascular diseases, and prompt us, The risk of hypertension is greater in the population with abnormal lipid metabolism, and it is necessary to pay special attention to the early screening of occult hypertension.
【作者单位】：重庆医科大学附属第一医院心血管内科;南昌大学医学院;
【基金】：国家重点专科建设项目(2011年):慢性病早期康复,筛查,心电监测及健康管理的规范技术推广项目(cstc-2015jcsf10012)资助
【分类号】：R544.1

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