Aberrant Activation of Cdc2/cyclin B1 Is Involved in Initiat

发布时间：2021-05-16 22:30

　　Niemann-Pick disease type C（NPC） is a fatal, neurovisceral lipid storage disease, neuropathologically characterized by cytoplasmic sequestration of glycolipids in neurons, progressive neuronal loss, neurofibrillary tangles（NFTs） formation, and axonal spheroids（AS）. Cytoskeletal pathology including accumulation of hyperphosphorylated cytoskeletal proteins is a neuropathological hallmark of the mouse model of NPC（npc mice）. With a goal of elucidating the mechanisms underlying the lesion formation,... 

【文章来源】：Journal of Huazhong University of Science and Technology（Medical Sciences）. 2017,37(05)SCI

【文章页数】：8 页

【文章目录】：
1 MATERIALS AND METHODS
    1.1 Npc Mice
    1.2 Brain Tissue
    1.3 Antibodies and Other Reagents
    1.4 Immunostaining
    1.5 Photographing and Imaging Process
    1.6 Immunoblotting Analysis
    1.7 Immunoprecipitation (IP) and Kinase Assay
    1.8 Statistical Analysis
2 RESULTS
    2.1 Cytoskeletal Lesions in Npc Mice at 3 Weeks of Age
    2.2 Activation of Mitotic Kinase is Synchronous with the Appearance of AS
    2.3 Cdk4/cyclin D1 Kinase Is Involved in Cytoskeletal Pathology
    2.4 Time Course of Cdc2, Cdk4, and Cdk5 Activation in Npc Mice
3 DISCUSSION
Conflict of Interest Statement


【参考文献】：
期刊论文
[1]TPPU Protects Tau from H2O2-induced Hyperphosphorylation in HEK293/tau Cells by Regulating PI3K/AKT/GSK-3β Pathway[J]. 姚恩生,唐燕,刘幸华,汪明欢.  Journal of Huazhong University of Science and Technology（Medical Sciences）. 2016(06)



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