伴有黄斑水肿的糖尿病视网膜病变患者脉络膜的光学相干断层扫描观察

发布时间：2018-01-21 06:55

本文关键词： 光学相干断层扫描糖尿病视网膜病变黄斑水肿脉络膜厚度　出处：《激光杂志》2014年02期 　论文类型：期刊论文

【摘要】：目的:使用频域光学相干断层扫描仪(Optical Coherence Tomography,OCT)观测伴有黄斑水肿的糖尿病视网膜病变患者中心凹下脉络膜厚度。方法:对50名患者的30只眼、10位正常人的15只眼实施通过黄斑中心凹水平和垂直扫描。30只患眼中15眼为不伴有临床显著意义黄斑水肿(clinically significant macular edema,CSME)眼,另外15只眼为伴有CSME水肿眼。用OCT自带的测量软件人工测出水平和垂直扫描线中心凹下脉络膜厚度,计算出平均数作为该眼中心凹下脉络膜厚度。结果:伴有和不伴有CSME眼的脉络膜厚度均比正常人脉络膜厚度薄,伴有CSME眼和不伴有CSME眼之间脉络膜厚度没有差异。结论:伴有黄斑水肿的糖尿病视网膜病变患者中心凹下脉络膜厚度较正常人薄,这可能导致组织缺氧而刺激血管内皮细胞生长因子表达增加,从而破坏血-视网膜屏障的完整性,最终导致黄斑水肿。
[Abstract]:Objective: to use frequency domain optical coherence tomography (OCTS) optical Coherence Tomography. Methods: 30 eyes of 50 patients with diabetic retinopathy with macular edema were studied. 15 eyes of 10 normal subjects underwent horizontal and vertical scanning through macular fovea. 15 eyes of the affected eyes were not associated with clinically significant macular edema (P < 0.05). Clinically significant macular edema. CSME edema was observed in the other 15 eyes. The thickness of the subcentral foveal choroid was measured manually by using the OCT software. Results: the choroidal thickness of the eyes with and without CSME was thinner than that of the normal eyes. There was no difference in choroidal thickness between the eyes with CSME and those without CSME. Conclusion: the thickness of subconcave choroid in diabetic retinopathy with macular edema is thinner than that in normal subjects. This may lead to tissue hypoxia and stimulate the expression of vascular endothelial growth factor (VEGF), thus destroying the integrity of blood-retinal barrier and eventually leading to macular edema.
【作者单位】：重庆医科大学附属第一医院;
【分类号】：R587.2;R774.1
【正文快照】： 糖尿病视网膜病变(diabetic retinopathy,DR)的主要病理生理改变即为视网膜血管屏障受损以及血流动力学异常,以致长期以来大量的研究集中在视网膜血管上,而对脉络膜血管的研究较少。脉络膜毛细血管为外层视网膜提供营养,维持光感受器细胞的高代谢状态。由于中心凹处神经网膜

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