96例鼻咽癌放疗后无进展生存者的生存质量分析

发布时间：2018-01-21 08:13

本文关键词： 鼻咽肿瘤放射疗法生存质量影响因素　出处：《新疆医科大学》2010年硕士论文　论文类型：学位论文

【摘要】： 目的:评估鼻咽癌放疗后无进展生存者的生存质量及相关影响因素,探讨调强放疗技术(IMRT)在改善鼻咽癌放疗后患者生存质量的意义。方法:参考FACT-HN量表,制定49项内容的“鼻咽癌患者生存质量调查问卷”。问卷调查2004年1月至2008年12月我院收治的有完整资料并经复查无进展的96例鼻咽癌患者放疗后的生存质量。通过SPSS16.0软件包处理数据,应用多元线性回归分析生存质量影响因素,将患者分为IMRT组及常规放疗组(CRT组),采用秩和检验比较两组特殊症状及治疗副反应领域评分。结果:鼻咽癌放疗后无进展生存者生存质量总得分为66.6±9.7,得分最低为功能状况。特殊症状及治疗副反应主要体现在不能进食固体食物、吞咽困难、口干、声音嘶哑方面。性别、年龄、婚姻、文化程度、家庭月人均收入、临床分期及放疗技术为生存质量独立影响因素。IMRT组及CRT组在进食情况、口干、声音嘶哑、交流情况、头晕头痛、耳鸣听力下降、龋齿、颈部活动受限、张口困难、记忆力下降、味觉减退方面的差异有统计学意义(P0.05)。结论:性别、年龄、婚姻、文化程度、家庭月人均收入、临床分期、放疗技术在多个维度上影响着鼻咽癌放疗后无进展生存者的生存质量。调强放疗技术在改善生存质量方面优于常规放疗技术。
[Abstract]:Objective: the quality of life and related factors of impact assessment of nasopharyngeal carcinoma after radiotherapy for progression free survival, of intensity-modulated radiotherapy (IMRT) in improving the quality of life of patients with nasopharyngeal carcinoma after radiotherapy. Methods: the FACT-HN scale, making 49 item "questionnaire of the quality of life in patients with nasopharyngeal carcinoma. The questionnaire survey from January 2004 to December 2008 in our hospital from the complete data and the review of 96 cases of progression free survival of patients with nasopharyngeal carcinoma after radiotherapy treatment. Quality of data through the SPSS16.0 software package, using multiple linear regression analysis of the factors affecting the quality of life, the patients were divided into IMRT group and conventional radiotherapy group (CRT group), rank sum test was used to compare two groups of special adverse symptoms and the treatment field score. Results: no survivors of nasopharyngeal carcinoma after radiotherapy quality of life total score progression was 66.6 + 9.7, the lowest score for functional status. Special symptoms and treatment side effects Mainly eat solid food, not in dysphagia, xerostomia, hoarseness. Gender, age, marriage, education level, family income per capita, clinical staging and radiotherapy are independent influencing factors of.IMRT group and CRT group in the eating, dry mouth, hoarseness, communication, dizziness and headache, tinnitus and hearing fall, dental caries, neck activity limitation, trismus, memory decline, decline the taste difference was statistically significant (P0.05). Conclusion: gender, age, marriage, education level, family monthly income per capita, clinical stage, radiotherapy quality of life in multiple dimensions affect the progression free survival after radiotherapy of nasopharyngeal carcinoma. IMRT technology in improving the quality of life is better than conventional radiotherapy techniques.

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R739.63

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