眼结膜黏膜相关淋巴组织边缘带B细胞淋巴瘤临床病理分析

发布时间：2018-01-24 00:09

本文关键词： 眼结膜肿瘤黏膜相关淋巴组织边缘带B细胞淋巴瘤免疫组织化学基因重排　出处：《临床与实验病理学杂志》2014年08期 　论文类型：期刊论文

【摘要】：目的探讨眼结膜黏膜相关淋巴组织边缘带B细胞淋巴瘤(marginal zone B cell lymphoma of mucosa-associated lymphoid tissue)(简称为MALT淋巴瘤)的临床病理特征、治疗及预后。方法对15例眼结膜MALT淋巴瘤患者的临床病理资料进行回顾性分析及随访,复查和完善HE及免疫组化染色切片,4例进行Ig基因重排克隆性分析。结果 (1)15例患者中,男性5例,女性10例,中位年龄42岁,病史平均20个月。(2)病理形态:黏膜下大量密集淋巴样细胞弥漫浸润,并有模糊淋巴滤泡样结节。浸润细胞多为小~中等大小的淋巴样细胞及单核样B细胞。(3)免疫表型:浸润细胞CD20、CD79a、BCL-2均(+),CD3、CD5、CD10、Cyclin D1、TdT均(-)。(4)Ig基因克隆性分析:4例均呈单克隆。(5)随访:随访时间2~35个月,截止随访日期,所有患者均生存,且病变无复发。结论眼结膜MALT淋巴瘤好发于中年女性,结膜红肿突起为主要特征,镜下以小细胞样边缘带B细胞为主,具有典型MALT淋巴瘤的免疫表型和惰性临床经过,预后良好。
[Abstract]:Objective to investigate B-cell lymphoma of conjunctival mucosa-associated lymphoid tissue. Marginal zone B cell lymphoma of mucosa-associated lymphoid tissue. The clinicopathological features of MALT lymphoma. Methods the clinicopathological data of 15 patients with conjunctival MALT lymphoma were retrospectively analyzed and followed up. Results among 15 patients with Ig, 5 were male and 10 were female. The median age was 42 years old. Pathological morphology: a large number of submucosal dense lymphoid cells diffuse infiltration. The infiltrating cells were mostly small to medium size lymphoid cells and mononuclear B cells. The immunophenotype of infiltrating cells was CD20 / CD79a. BCL-2 were all (CD3, CD5, CD10, Cyclin D1). Clonality Analysis of Ig Gene of TdT: 4 cases were all presented as Monoclonal. 5) follow up: the follow-up time was 2 ~ 35 months, and all the patients survived at the end of follow-up date. Conclusion Conjunctival MALT lymphoma is more common in middle-aged women with redness and redness of conjunctiva as the main feature, and B cells in small cell-like marginal zone are dominant under microscope. The immunophenotypic and inert clinical course of typical MALT lymphoma has a good prognosis.
【作者单位】：首都医科大学附属北京友谊医院病理科;内蒙古包头医学院第一附属医院病理科;内蒙古包头医学院病理学教研室;青海医学院附属医院病理科;河北医科大学第二医院病理科;首都医科大学附属北京朝阳医院病理科;
【分类号】：R739.7
【正文快照】： 黏膜相关淋巴组织边缘带B细胞淋巴瘤(mar-ginal zone B cell lymphoma of mucosa-associatedlymphoid tissue)简称MALT淋巴瘤,2008年WHO造血与淋巴组织瘤分类中将其视为边缘带B细胞淋巴瘤中具有独特临床病理特征的一类疾病[1],占所有B细胞淋巴瘤的7%~8%,其具有惰性临床过程及

【参考文献】