海南地区慢性鼻-鼻窦炎患者吸入性变应原血清检测结果分析

发布时间：2018-01-24 15:08

本文关键词： 慢性鼻-鼻窦炎变应原特异性IgE　出处：《实用医学杂志》2014年15期 　论文类型：期刊论文

【摘要】：目的:通过检测海南地区慢性鼻-鼻窦炎(CRS)患者血清变应原,了解海南地区主要吸入性变应原分布情况,探讨有效实施变应原避免的措施,为成功开展特异性免疫治疗提供依据。方法:用UniCAP100全自动变应原检测仪对318例CRS患者进行吸入物变应原过筛试验(Phadiatop)并检测7种常见变应原的血清特异性IgE(specific IgE,SIgE)水平,同时检测其血清总IgE(total IgE,TIgE)水平。结果:血清TIgE阳性率为64.15%,吸入变应原过筛实验阳性率为37.74%。SIgE阳性的总发生率为33.96%。其中户尘螨(28.30%)、热带螨(27.36%)、粉尘螨(21.07%)、蟑螂(13.52%)、屋尘(11.64%)、猫皮屑(7.86%)、狗皮屑(0.63%)。在伴鼻息肉的CRS和不伴鼻息肉的CRS之间,TIgE阳性及SIgE阳性的发生率比较差异均无统计学意义。结论:户尘螨、热带螨、粉尘螨是海南地区CRS患者主要的吸入性变应原。
[Abstract]:Objective: to investigate the distribution of main inhaled allergens in patients with chronic rhinosinusitis (CRS) in Hainan and to explore the effective measures to avoid allergens. Methods: a total of 318 patients with CRS were tested for inhaled allergen by UniCAP100 automatic allergen test (UniCAP100). The sero-specific IgE(specific IgE of 7 common allergens were detected by Phadiatop. Results: the positive rate of serum TIgE was 64.15%. The positive rate of inhaled allergen screening test was 37.74. The total incidence of IgE positive was 33.96. Among them, the dust mites were 28.30 and the tropical mites were 27.36. Dust mites 21.07, cockroaches 13.52, house dust 11.64, cat dandruff 7.86). There was no significant difference in the incidence of CRS and SIgE between CRS with nasal polyps and CRS without nasal polyps. Tropical mites and Dermatophagoides farinae are the main inhaled allergens in patients with CRS in Hainan.
【作者单位】：四川大学华西医院;海南医学院附属医院耳鼻咽喉科;海南医学院附属新华医院耳鼻咽喉科;海南医学院附属医院病理科;
【基金】：海南省自然科学基金(编号:309069)
【分类号】：R765.4;R446.6
【正文快照】： 慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)是临床常见病、多发病。根据美国的统计资料,其发病率在成人中超过15%,并有逐渐增加的趋势[1]。随着研究的进一步深入,变态反应对CRS的病理形成、发展及预后的影响也日益凸现。了解CRS患者的变应原谱,采取具有针对性的CRS的防治对

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