新西兰大白兔球周注射曲安奈德后的病理变化

发布时间：2018-01-26 17:15

本文关键词： 曲安奈德球周注射病理变化　出处：《新疆医科大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：研究曲安奈德(triamcinolone acetonide,TA)球周注射后球周组织的病理形态学的改变。方法：纯种新西兰大白兔24只,随机分成2组即组A和组B，每组12只。A组为对照组，双眼球周注射生理盐水（Phosphate Buffered Saline，PBS）0.5ml；B组为实验组，双眼球周注射TA（40mg/ml）0.5ml,每只动物于注药前,注药后第1周，第2周，第3周双眼行眼压测量记录,进行统计学分析，每组于第4周,第8周,第12周分别处死4只兔子，取眼球运动肌，哈氏腺，眶内脂肪组织，视神经行光学和电子显微镜检查。结果：各组兔眼注药前，注药后第1周，，第2周，第3周的眼压波动,差异无统计学意义(P0.01);光学和电子显微镜检查显示B组（实验组）运动肌，哈氏腺均有不同程度的组织结构损害，脂肪组织，视神经未见明显病理变化。A组球周组织未见明显异常。结论：新西兰大白兔球周注射TA注射液可诱导眼球运动肌萎缩并可诱发哈氏腺增生性改变。
[Abstract]:Objective: to study triamcinolone acetonide. Methods: Twenty-four purebred New Zealand white rabbits were randomly divided into two groups: group A (n = 12) and group B (n = 12). Intraocular injection of Phosphate Buffered Salinesil 0.5 ml; Group B was treated with intraocular injection of TA40 mg / ml 0.5 ml. The intraocular pressure was measured before injection, 1 week, 2 weeks and 3 weeks after injection. In each group, 4 rabbits were killed at week 4, week 8 and week 12, respectively. Results: the intraocular pressure fluctuated in the first week, the second week and the third week before and after the injection of the drug in the eyes of the rabbits, and there was no significant difference in the intraocular pressure between the two groups (P 0.01). Optical and electron microscopic examination showed that in group B (experimental group), there were different degrees of tissue structure damage and adipose tissue. There were no obvious pathological changes in optic nerve. There was no obvious abnormality in peribulbar tissue in group A. conclusion: TA injection in New Zealand rabbits can induce atrophy of ocular motor muscle and induce hyperplastic change of Hardler gland.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R77

【参考文献】