真性糖尿病性白内障患者超声乳化术后角膜神经和泪液蛋白的特点

发布时间：2018-02-09 08:40

本文关键词： 超声乳化白内障吸除术糖尿病角膜共焦显微镜角膜知觉　出处：《中国糖尿病杂志》2014年03期 　论文类型：期刊论文

【摘要】：目的探讨真性糖尿病性白内障(TDC)患者超声乳化术后眼表症状、角膜神经和泪液蛋白的特点。方法 TDC患者56例(右眼),随机分为两组,A组采用上方透明角膜切口,B组采用颞侧透明角膜切口,均行超声乳化白内障吸除联合人工晶状体(IOL)植入术,分别于术前、术后1周、2周、1个月及3个月行眼表症状评分、泪液蛋白测定、角膜知觉计检查和共聚焦显微镜检查。结果术前两组干眼各眼表症状评分、泪液蛋白、乳铁蛋白、溶菌酶、神经纤维密度及角膜敏感度比较,差异均无统计学意义(P0.05);术后2周,两组干涩感、异物感、畏光、疼痛、眼红和流泪症状比较,差异均有统计学意义(P0.05);术后3个月,两组各症状和泪液总蛋白量、乳铁蛋白、溶菌酶及神经纤维密度比较,差异均无统计学意义(P0.05),但角膜敏感度、角膜切口连接型神经比较,差异有统计学意义(P0.05)。角膜切口中形态异常的神经纤维在B组中出现的几率高于A组(P0.05)。结论对于TDC,上方切口行超声乳化联合IOL植入术可以改善角膜知觉,减轻角膜切口神经损伤,提高患者的视觉质量。
[Abstract]:Objective to investigate the ocular surface symptoms after phacoemulsification in patients with true diabetic cataract (TDC). Methods 56 patients with TDC (right eye) were randomly divided into two groups: group A was treated with superior transparent corneal incision and group B was treated with temporal clear corneal incision. Phacoemulsification combined with IOL implantation was performed. The ocular surface symptom score and tear protein were measured before, 1 week, 1 month and 3 months after operation, respectively. Results there was no significant difference in the scores of dry eye surface symptoms, lacrimal protein, lactoferrin, lysozyme, nerve fiber density and corneal sensitivity between the two groups before and after operation (P 0.05). There were significant differences in dry feeling, foreign body sensation, photophobia, pain, eye redness and tears between the two groups (P 0.05). 3 months after operation, the contents of total protein, lactoferrin, lysozyme and nerve fiber density were compared between the two groups. The difference was not statistically significant (P 0.05), but the corneal sensitivity, corneal incision connective nerve, The difference was statistically significant (P 0.05). The frequency of appearance of abnormal nerve fibers in the corneal incision in group B was higher than that in group A. conclusion for TDC, phacoemulsification combined with IOL implantation in the upper incision can improve corneal perception and reduce nerve injury of corneal incision. Improve the visual quality of patients.
【作者单位】：南昌大学第一附属医院眼科;南昌市第三医院内分泌科;厦门大学附属厦门眼科中心;
【基金】：国家自然科学基金(81160118) 全国临床医药研究专项基金(L2012052) 江西省科技支撑计划项目(20111BBG70026-2) 江西省自然科学基金(20114BAB215029) 江西省卫生厅中医药科技计划项目(2012A085) 福建省卫生厅科研基金资助项目(2011-2-79)
【分类号】：R587.2;R779.66

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