悬雍垂组织病理学改变与阻塞性睡眠呼吸暂停低通气综合征关系的研究

发布时间：2018-02-10 19:23

本文关键词： 阻塞性睡眠呼吸暂停综合征悬雍垂病理改变　出处：《牡丹江医学院学报》2011年02期 　论文类型：期刊论文

【摘要】：目的:通过对OSAHS患者和无OSAHS病史男尸的悬雍垂病理组织学的研究,探讨悬雍垂组织的病理学变化与OSAHS的关系。方法:采用34例因OSAHS而进行部分保留悬雍垂的腭咽成形术切除的悬雍垂作为实验组,其中24例为重度阻塞,中度阻塞10例;取无OSAHS病史的男性尸检悬雍垂10为对照组。光镜下观察其组织结构的改变,主要对肌肉纤维的形态、密度以及排列状态进行观察,并对肌间的组织以及上皮组织结构进行观察,用半定量分析法对结果进行分析。结果:与对照组相比较,OSAHS组悬雍垂粘膜上皮层结构尚完整,但伴有明显的炎症表现,固有层厚度为0.92±0.21mm,对照组为0.24±0.07mm,P0.01;同时,不同程度OSAHS、不同程度体块指数患者的粘膜固有层厚度的比较均有显著性差异。OSAHS组的悬雍垂肌纤维密度为85.47±29.54,对照组为149.70±22.68,P0.01;重度OSAHS悬雍垂肌纤维密度为72.04±14.47,中度重度OSAHS为117.70±32.09,P0.01。对照组中肌纤维的排列整齐、连接紧密、形态规整,实验组绝大部分悬雍垂肌纤维标本排列不规则,而且随着的OSAHS程度的加重,其排列越混乱。结论:OSAHS患者的悬雍垂从粘膜到肌肉都发生明显的病理改变,出现粘膜固有层增厚,肌纤维密度减少和肌纤维排列混乱、变性等表现,并且随着OSAHS程度的加重而加剧。提示悬雍垂组织的病理改变与OSAHS发生、发展有密切的相关性。
[Abstract]:Objective: to study the histopathology of uvula in OSAHS patients and male cadavers without history of OSAHS. To investigate the relationship between pathological changes of uvula and OSAHS. Methods: 34 cases of uvula were treated with partial uvula preserving palatopharyngoplasty because of OSAHS, 24 cases were severe obstruction, 10 cases were moderate obstruction. Male autopsy with no history of OSAHS was used as control group. The changes of tissue structure were observed under light microscope. The morphology, density and arrangement of muscle fibers were observed, and the structure of muscle tissue and epithelial tissue were observed. Results: compared with the control group, the epithelial layer of uvula mucosa in OSAHS group was still intact, but with obvious inflammation, the thickness of lamina propria was 0.92 卤0.21 mm and that of control group was 0.24 卤0.07 mm P 0.01. The density of uvula muscle fiber in OSAHS group was 85.47 卤29.54, that in control group was 149.70 卤22.68 P 0.01, that of severe OSAHS uvula muscle was 72.04 卤14.47, and that of moderate severe OSAHS was 72.04 卤14.47, and that of OSAHS group was 85.47 卤29.54, that of control group was 149.70 卤22.68 P 0.01, that of severe OSAHS uvula muscle was 72.04 卤14.47, that of control group was 72.04 卤14.47. 117.70 卤32.09m P0.01.The arrangement of muscle fibers in the control group was neat, Most of the uvula muscle fibers in the experimental group were arranged irregularly, and with the increase of the degree of OSAHS, the arrangement became more chaotic. Conclusion the uvula of the patients with OSAHS has obvious pathological changes from mucous membrane to muscle. The thickening of lamina propria, the decrease of muscle fiber density, the disorder and degeneration of muscle fiber arrangement, and so on, are aggravated with the aggravation of OSAHS. It is suggested that the pathological changes of uvula tissue are closely related to the occurrence and development of OSAHS.
【作者单位】：广西医科大学第一附属医院耳鼻咽喉头颈外科;
【分类号】：R766

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