胸苷磷酸化酶在鼻咽癌中的表达及临床意义

发布时间：2018-02-10 19:55

本文关键词： 鼻咽癌胸苷磷酸化酶化疗预后　出处：《南昌大学》2011年硕士论文　论文类型：学位论文

【摘要】：目的：探讨胸苷磷酸化酶(thymidine phosphorylase, TP)在鼻咽癌中的表达及临床意义。方法：采用免疫组化方法(Elivision法)检测了51例鼻咽癌组织和10例鼻粘膜炎及10例鼻息肉组织中TP的表达,并探讨鼻咽癌组织中胸苷磷酸化酶与临床病理因素、氟尿嘧啶类药物化疗疗效及预后之间的关系。结果： (1)在51例鼻咽癌组织中,有35例(68.8%)TP表达阳性,与鼻粘膜炎及鼻息肉组织中的TP表达(分别为30%和20%)差异显著(P值分别为0.032和0.01)。 (2)鼻咽癌组织中TP表达与年龄、性别、T分期、N分期、TNM分期、颅神经侵犯、复发或远处转移等临床病理因素均无明显相关性(P0.05) (3)对行含氟尿嘧啶类药物方案化疗的鼻咽癌亚群进行生存分析,TP阳性组与TP阴性组的总生存率差异无显著性意义(P值为0.685) (4)对51例鼻咽癌病人进行生存分析,TP阳性组与TP阴性组的3年、4年总生存率差异无显著性意义。多因素Cox模型分析显示复发或远处转移为影响鼻咽癌预后的独立因素,TP表达不是影响鼻咽癌预后的独立因素。结论： TP在鼻咽癌组织中高表达,明显高于鼻粘膜炎及鼻息肉组织中TP的表达量。鼻咽癌组织中的TP表达与临床病理因素均无明显相关性。行含氟尿嘧啶类药物方案化疗的鼻咽癌亚群中TP阳性组与TP阴性组的预后差异无显著性意义,多因素Cox模型分析显示TP表达并非是影响鼻咽癌预后的独立因素。
[Abstract]:Objective:. To investigate the expression and clinical significance of thymidine phosphorylase (TP) in nasopharyngeal carcinoma (NPC). Methods:. The expression of TP in 51 cases of nasopharyngeal carcinoma (NPC), 10 cases of nasal mucositis and 10 cases of nasal polyps was detected by immunohistochemical method. Relationship between chemotherapy efficacy and prognosis of fluorouracil drugs. Results:. (1) in 51 cases of nasopharyngeal carcinoma, there were 35 cases with positive expression of TP, which was significantly different from that in nasal mucositis and nasal polyps (30% and 20) (P = 0.032 and 0.01, respectively). (2) there was no significant correlation between TP expression in nasopharyngeal carcinoma and age, sex T staging, TNM stage, cranial nerve invasion, recurrence or distant metastasis (P 0.05). Survival analysis of nasopharyngeal carcinoma subsets treated with fluorouracil regimen; there was no significant difference in overall survival rate between TP positive group and TP negative group (P = 0.685). Survival analysis of 51 patients with nasopharyngeal carcinoma the 3-year and 4-year overall survival rates of TP positive group and TP negative group were not significantly different. Multivariate Cox model analysis showed that recurrence or distant metastasis was an independent factor affecting the prognosis of nasopharyngeal carcinoma. The expression of TP is not an independent factor for the prognosis of nasopharyngeal carcinoma. Conclusion:. TP was highly expressed in nasopharyngeal carcinoma. There was no significant correlation between TP expression and clinicopathological factors in nasopharyngeal carcinoma. TP positive group in nasopharyngeal carcinoma subpopulation with fluorouracil regimen chemotherapy was significantly higher than that in nasal polyps and nasal mucositis tissues, and there was no significant correlation between TP expression and clinicopathological factors in nasopharyngeal carcinoma tissues. There was no significant difference in prognosis between TP negative group and TP negative group. Multivariate Cox analysis showed that TP expression was not an independent factor for the prognosis of nasopharyngeal carcinoma.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R739.63

【参考文献】