丝裂霉素C结膜下注射联合那素达滴眼液在翼状胬肉手术中的临床应用

发布时间：2018-02-20 21:04

本文关键词： 翼状胬肉丝裂霉素C 那素达羊膜角膜缘干细胞　出处：《武汉大学学报(医学版)》2014年01期 　论文类型：期刊论文

【摘要】：目的:探讨术前低浓度丝裂霉素C(MMC)结膜下注射联合术后那素达(盐酸萘甲唑啉马来酸非尼拉敏)滴眼液治疗翼状胬肉的临床疗效。方法:将翼状胬肉随机分为3组,A组(实验组):术前低浓度MMC结膜下注射联合术后那素达滴眼组68例(80只眼);B组(对照组1):翼状胬肉切除联合MMC及羊膜移植术组64例(77只眼);C组(对照组2):翼状胬肉切除联合MMC及自体角膜缘干细胞移植术组63例(73只眼)。术后1周,2周,1月,3月,1年,2年检查记录术眼并发症及复发情况。结果:随访观察6-24个月,A组3只眼复发(3.75%);B组10只眼复发(12.99%);C组9只眼复发(12.33%)。A组与B组、C组对比差异有统计学意义(P0.05),B组与C组对比差异无统计学意义(P0.05)。结论:术前低浓度MMC结膜下注射联合术后那素达滴眼并发症少,可有效预防翼状胬肉复发。
[Abstract]:Objective: to investigate the clinical effect of preoperative subconjunctival injection of low concentration mitomycin (MMC) and postoperative nalcitrate (nalcitrate) eye drops in the treatment of pterygium. Methods: pterygium was randomly divided into 3 groups. Group A (experimental group): preoperative low concentration MMC subconjunctival injection combined with postoperative nalcitrate drop in 68 patients with 80 eyes in group B (control group 1): pterygium excision combined with MMC and amniotic membrane transplantation group (64 cases, 77 eyes), group C (control group, 2 pterygoid); In the pterygium excision combined with MMC group and limbal stem cell autograft transplantation group, 63 cases (73 eyes) were examined and recorded the complications and recurrence of the operation 1 week after operation for 2 weeks, January, March, 1 year and 2 years. Results: 3 eyes of group A were followed up for 6 to 24 months. There was significant difference between group A and group B (P 0.05). There was no significant difference between group B and group C. conclusion: subconjunctival injection of low concentration of MMC before and after operation. The complications of eye drops are less, It can effectively prevent the recurrence of pterygium.
【作者单位】：三峡大学仁和医院;三峡大学眼科研究所;
【分类号】：R779.6

【参考文献】