超前镇痛在鼻内镜手术术中及术后的镇痛效果研究

发布时间：2018-02-27 01:27

本文关键词： 超前镇痛帕瑞昔布钠喷他佐辛内镜术　出处：《临床耳鼻咽喉头颈外科杂志》2014年17期 　论文类型：期刊论文

【摘要】：目的:评价帕瑞昔布钠和喷他佐辛超前镇痛应用于鼻内镜手术术中及术后的镇痛效应,为临床合理应用超前镇痛提供参考。方法:以120例局部麻醉鼻内镜下行鼻中隔矫正加鼻甲射频消融术的患者为研究对象,随机分为帕瑞昔布钠组(A组)、喷他佐辛组(B组)及对照组(C组),每组40例;分别于术前30min单次肌内注射帕瑞昔布钠40mg、喷他佐辛30mg及相同容积生理盐水。采用视觉模拟评分(VAS)评估3组患者术中和术后3、24、48h的疼痛情况,同时记录术后追加镇痛药使用情况及药物相关不良反应的发生情况。结果:与C组相比,A组及B组在术中和术后3、24、及48h的VAS均显著降低(P0.05)。与C组相比,A组与B组术后追加镇痛药使用率减少(P0.05)。结论:局部麻醉鼻内镜下鼻中隔矫正加鼻甲射频消融术前给予帕瑞昔布钠和喷他佐辛均可收到良好的超前镇痛效果,安全性较高,值得在临床工作中推广应用。
[Abstract]:Objective: To evaluate the analgesic effect of parecoxib sodium and pentazocine preemptive analgesia in nasal endoscopic surgery and after the surgery, to provide reference for clinical rational use of preemptive analgesia. Methods: 120 patients with local anesthesia plus endoscopic nasal turbinate radiofrequency ablation as the research object, randomly divided into parecoxib celecoxib sodium group (A group), pentazocine group (B group) and control group (C group), 40 cases in each group respectively; preoperative 30min single intramuscular injection of parecoxib sodium 40mg, pentazocine 30mg and the same volume of saline. Using visual analogue score (VAS) pain 3,24,48h and postoperative assessment of 3 groups of patients were recorded at the same time, occurrence of post-operative analgesic drug use and drug related adverse reactions. Results: compared with C group, A group and B group in the intraoperative and postoperative 3,24, 48h and VAS were significantly decreased (P0.05). Compared with the C group. A group and B group after operation Supplementary analgesia was decreased (P0.05). Conclusion: local anesthesia in endoscopic nasal septum and inferior turbinate radiofrequency ablation before parecoxib sodium and pentazocine can receive better analgesia effect, high safety, and is worthy of popularization and application in clinical work.

【作者单位】：武汉大学人民医院耳鼻咽喉头颈外科;
【分类号】：R765.9

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