IL-25和嗜酸粒细胞在变应性鼻炎及鼻息肉组织中的表达及意义

发布时间：2018-03-03 00:26

本文选题：IL-　切入点：嗜酸粒细胞　出处：《临床耳鼻咽喉头颈外科杂志》2014年18期 　论文类型：期刊论文

【摘要】：目的:观察IL-25和嗜酸粒细胞(EOS)在变应性鼻炎及鼻息肉组织中的表达与意义,探讨IL-25与EOS在其发病中的可能作用及内在联系。方法:采用免疫组织化学SP法检测33例变应性鼻炎患者(变应性鼻炎组)、31例鼻息肉患者(鼻息肉组)及30例单纯鼻中隔偏曲患者(对照组)局部组织中IL-25的表达情况;苏木精-伊红染色观察炎性细胞浸润情况并计数,进行比较分析。结果:1变应性鼻炎组IL-25阳性细胞数与对照组相比差异有统计学意义(P0.05),IL-25表达情况与EOS局部浸润数呈正相关(r=0.652,P0.01);2鼻息肉组IL-25阳性细胞计数与对照组相比差异有统计学意义(P0.05),IL-25表达情况与EOS局部浸润数呈正相关(r=0.88,P0.01)。结论:变应性鼻炎和鼻息肉组织中IL-25的表达均明显增强,变应性鼻炎和鼻息肉组织中可见大量EOS浸润,两者呈正相关。提示IL-25及EOS均参与了变应性鼻炎和鼻息肉的发病过程,IL-25对EOS的趋化、聚集作用不可忽视,并在变应性鼻炎和鼻息肉的形成过程中发挥重要作用。
[Abstract]:Objective: to investigate the expression and significance of IL-25 and eosinophil in allergic rhinitis and nasal polyps. To explore the possible role of IL-25 and EOS in the pathogenesis of rhinitis and their internal relationship. Methods: 33 patients with allergic rhinitis (allergic rhinitis) and 30 patients with nasal polyps (nasal polyps) and 30 patients with nasal polyps were detected by immunohistochemical SP method. The expression of IL-25 in the local tissues of patients with nasal septum deviation (control group); Hematoxylin-eosin staining was used to observe the infiltration of inflammatory cells. Results the number of IL-25 positive cells in the allergic rhinitis group was significantly different from that in the control group. There was a positive correlation between the expression of IL-25 and the number of local EOS infiltration. There was a positive correlation between the number of IL-25 positive cells in the nasal polyp group and that in the control group. There was a positive correlation between the expression of IL-25 and the number of local invasion of EOS. Conclusion: the expression of IL-25 in allergic rhinitis and nasal polyps was significantly increased. A large number of EOS infiltrations were observed in allergic rhinitis and nasal polyps, which showed that IL-25 and EOS were both involved in the chemotaxis of EOS in the pathogenesis of allergic rhinitis and nasal polyps. It also plays an important role in the formation of allergic rhinitis and nasal polyps.
【作者单位】：苏北人民医院耳鼻咽喉头颈外科;扬州大学医学院;
【分类号】：R765.21

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