冠心病和阻塞性睡眠呼吸暂停综合征相关性的临床研究

发布时间：2018-03-04 20:52

本文选题：冠心病　切入点：睡眠呼吸暂停　出处：《浙江大学》2010年硕士论文　论文类型：学位论文

【摘要】： 目的：探讨冠心病(coronary artery disease, CAD)与阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea syndrome, OSAS)之间的相关性。方法：选择2008年6月至2009年3月因胸闷胸痛及夜间心绞痛疑诊冠心病来我院心内科住院的52例患者,监测生命体征,行冠状动脉造影,冠脉造影前或后进行睡眠监测。空腹抽血测甘油三酯,胆固醇水平,行心电图、超声心动图检查,计算体重指数(body mass index, BMI)及了解有无患高血压、糖尿病情况。结果：将患者分成对照组(冠脉造影阴性),冠心病组(冠脉造影阳性)。对照组21例,其中OSAS 13例(61.9%),冠心病组31例,OSAS 25例(80.6%)。统计分析两组之间睡眠呼吸紊乱指数、最低氧饱和度及定量评估冠脉狭窄程度(Gensini评分)、甘油三酯水平差异有统计学意义(P0.05)。两组之间胆固醇水平,高血压和糖尿病的患病率差异没有统计学意义。Logistic回归分析得出,吸烟和AHI20为冠心病发病的危险因素,OR值分别为6.603和4.883。结论：冠心病和阻塞型睡眠呼吸暂停低通气综合征密切相关,AHI20是冠心病的危险因素之一,应引起足够的重视。
[Abstract]:Objective: To investigate the correlation between coronary artery disease (CAD) and obstructive sleep apnea syndrome (OSAS) in patients with obstructive sleep apnea hypopnea syndrome.
Methods: 52 cases from June 2008 to March 2009 because of chest pain and nocturnal angina suspected coronary heart disease in our hospital department of Cardiology hospitalized patients, monitoring the vital signs, coronary angiography, coronary angiography before and after sleep monitoring. Fasting blood test triglyceride, cholesterol level, electrocardiogram, echocardiography, body mass index (body mass index, BMI) and know whether the risk of high blood pressure, diabetes.
Results: the patients were divided into control group (CAG), coronary heart disease group (positive coronary angiography). The control group of 21 cases, including 13 cases of OSAS (61.9%), 31 cases of coronary heart disease, 25 cases of OSAS (80.6%). Statistical analysis between the two groups of sleep apnea hypopnea index, the lowest oxygen saturation and quantitative assessment of coronary artery stenosis degree (Gensini score), statistically significant differences in the level of triglyceride (P0.05) between the two groups. Cholesterol levels, prevalence of hypertension and diabetes was not statistically significant.Logistic regression analysis showed that smoking and AHI20 are the risk factors of coronary artery disease, OR = 6.603 and 4.883. conclusion: coronary heart disease and obstructive sleep apnea hypopnea syndrome is closely related, AHI20 is one of the risk factors of coronary heart disease, should cause enough attention.

【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R766;R541.4

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