半胱氨酸白三烯表达在阻塞性睡眠呼吸暂停低通气综合征中的临床研究

发布时间：2018-03-05 00:14

本文选题：半胱氨酸白三烯　切入点：阻塞性睡眠呼吸暂停低通气综合征　出处：《中国临床药理学杂志》2015年21期 　论文类型：期刊论文

【摘要】：目的探讨半胱氨酸白三烯(Cys LTs)表达在诊断阻塞性睡眠呼吸暂停低通气综合征(OSAHS)中的临床研究。方法纳入76例疑似打鼾患儿为研究对象。其中经多导睡眠仪确诊为OSAHS的40例患儿为试验组,其余36例为对照组。用竞争酶联免疫吸附试验检测2组患儿血清Cys LTs表达水平,评价血清Cys LTs诊断OSAHS的敏感性、特异性、阳性预测值、阴性预测值及诊断试验的受试者工作特征(ROC)曲线下面积。结果试验组患儿血清Cys LTs水平为(702.8±85.1)ng·L-1,对照组为(487.2±81.6)ng·L-1,试验组显著高于对照组(P0.05)。试验组中病情轻度组Cys LTs水平显著低于中、重度组(P0.05);根据贝叶斯定理绘制ROC曲线下面积为0.82(95%CI:0.74~0.89),Cys LTs的最佳截断值为627 ng·L-1,在该截断值下,诊断的敏感性为88.8%,特异性为82.5%。结论血清Cys LTs表达水平在OSAHS患儿中显著升高并与病情严重程度存在相关性,可作为OSAHS的血清标志物。
[Abstract]:Objective to investigate the clinical significance of cysteine leukotriene (Cys LTs) expression in the diagnosis of obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 76 children with suspected snoring were included in the study. 40 cases of OSAHS were used as experimental group. The other 36 cases were used as control group. The expression of serum Cys LTs was detected by competitive enzyme-linked immunosorbent assay (Elisa), and the sensitivity, specificity and positive predictive value of serum Cys LTs in the diagnosis of OSAHS were evaluated. Results the serum Cys LTs level was 702.8 卤85.1 ng 路L -1 in the test group and 487.2 卤81.6 ng 路L -1 in the control group, which was significantly higher than that in the control group (P 0.05). The level of Cys LTs in the mild group was significantly lower than that in the control group. According to Bayesian theorem, the optimum truncation value of the area under the ROC curve is 0.82% 95% CI: 0.74 0.89% Cys LTs is 627 ng 路L ~ (-1), and the best truncation value is 627 ng 路L ~ (-1). Conclusion the expression of serum Cys LTs is significantly higher in children with OSAHS and is correlated with the severity of the disease. It can be used as a serum marker of OSAHS.
【作者单位】：浙江中医药大学附属温州中西医结合医院耳鼻咽喉科;
【基金】：温州市科技计划基金资助项目(2014S0216)
【分类号】：R766

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