持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征患者血液流变学、hs-CRP水平的影响

发布时间：2018-03-05 06:02

本文选题：睡眠呼吸暂停综合征　切入点：持续气道正压通气　出处：《实用医学杂志》2015年07期 　论文类型：期刊论文

【摘要】：目的:观察持续气道正压通气(CPAP)治疗对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血液流变学、超敏C反应蛋白(hs-CRP)的影响。方法:中重度OSAHS患者58例,纳入治疗组,门诊体检健康者32例,纳入对照组,检测两组受试者血液流变学、hs-CRP水平,比较两组间的差异;治疗组经CPAP治疗3个月后再检测血液流变学、hs-CRP水平,比较治疗前后的差异。结果:治疗组全血黏度(高切、中切和低切)、红细胞压积(HCT)、hs-CRP水平均高于对照组,差异有统计学意义(P0.01);治疗组经CPAP治疗后全血黏度(高切、中切和低切)、HCT、hs-CRP水平较治疗前明显降低,差异有统计学意义(P0.01)。结论:OSAHS患者血液流变学、hs-CRP水平升高,CPAP治疗能有效地降低患者血液流变学、hs-CRP水平。
[Abstract]:Objective: to observe the effect of continuous positive airway pressure (CPAP) therapy on hemorheology and hypersensitive C-reactive protein (hs-CRP) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: 58 patients with moderate and severe OSAHS were included in the treatment group. 32 healthy outpatients were included in the control group to detect the level of hs-CRP in hemorheology of the two groups, and to compare the difference between the two groups, and to detect the level of hs-CRP in the treatment group after 3 months of CPAP treatment. Results: the whole blood viscosity (high cut, middle cut and low cut), HCT hs-CRP levels in the treatment group were higher than those in the control group, the difference was statistically significant (P 0.01), and the whole blood viscosity (high shear rate) after CPAP treatment in the treatment group was higher than that in the control group. The level of HCThs-CRP was significantly lower than that before treatment, and the difference was statistically significant (P 0.01). Conclusion the level of hs-CRP in patients with OSAHS is higher than that before treatment. CPAP can effectively reduce the level of Hemorheology hs-CRP in patients with OSAHS.
【作者单位】：广东省佛山市禅城区中心医院呼吸内科;
【分类号】：R766

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