Avastin在老年黄斑变性治疗中的作用

发布时间：2018-03-12 12:18

本文选题：Avastin　切入点：老年黄斑变性　出处：《中国老年学杂志》2014年18期 　论文类型：期刊论文

【摘要】：目的观察Avastin在老年黄斑变性治疗中的作用。方法随诊2007年12月至2009年7月在该院住院行玻璃体腔内注射Avastin的老年黄斑变性患者43例,注射后随诊6~12个月,应用眼底检查、眼底照相、光学相关断层扫描(OCT)检查等观察患者黄斑区渗出、出血吸收情况,新生血管消退情况,视力、眼压变化及并发症情况。结果注射Avastin后1 d,39例患者主诉眼前黑影明显减小,36例患者视力不同程度改善,所有患者视力平均提高1.5行,4例患者症状无改善;注射后1 w、1、2、6、12 m,患者视力分别平均提高2.7行、3行、3.5行、2.8行和2.5行,OCT检查示黄斑中心凹厚度明显分别为(312.35±65.07)μm、(266.39±56.87)μm、(257.01±68.29)μm、(298.08±64.09)μm和(309.37±84.32)μm〔术前(325.03±87.12)μm〕,FFA或IGCA检查示黄斑区见荧光渗漏注射后1 w起明显减少,注射后1 m部分患者再次出现荧光渗漏,随注射时间延长,渗漏者增多,所有患者随诊无明显全身及局部并发症。结论 Avastin可作为老年黄斑变性治疗的有效方法,为老年黄斑变性的治疗带来新的希望,但作用时间短,需要重复注射。
[Abstract]:Objective to observe the role of Avastin in the treatment of senile macular degeneration. Methods from December 2007 to July 2009, 43 cases of senile macular degeneration who received intravitreal injection of Avastin were followed up for 6 ~ 12 months. Fundus photography and optical correlation tomography (OCTT) were used to observe macular exudation, bleeding and absorption, receding neovascularization, visual acuity, etc. Results one day after injection of Avastin, 39 patients complained of significant reduction of visual acuity in 36 patients. The visual acuity of all patients was improved by an average of 1. 5 lines and 4 patients had no improvement in symptoms. 1 week after injection, the visual acuity of the patients increased by 2.7 lines, 3 lines, 3.5 lines, 2.8 lines and 2.5 lines, respectively. The thickness of macular fovea was 312.35 卤65.07 渭 m, 266.39 卤56.87 渭 m, 257.01 卤68.29 渭 m, 298.08 卤64.09 渭 m and 309.37 卤84.32 渭 m (325.03 卤87.12) 渭 m FFA or IGCA showed a significant decrease in macular area. Fluorescence leakage occurred again in some patients 1 m after injection. With the prolongation of injection time, the number of leakage increased, and there were no obvious systemic or local complications in all patients. Conclusion Avastin can be used as an effective method for the treatment of senile macular degeneration. New hope for the treatment of senile macular degeneration, but short duration, need repeated injection.
【作者单位】：潍坊医学院附属医院眼科;
【基金】：山东省教育厅科学基金项目(No.J10LF69) 潍坊市科技局自然科学基金项目(No.200702034)
【分类号】：R774.5

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