程序化细胞死亡分子5（PDCD5）在喉癌中的表达及意义

发布时间：2018-03-14 01:41

本文选题：喉癌　切入点：蛋白印迹法　出处：《延边大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：探讨程序化细胞死亡分子5(programmed cell death5, PDCD5)在喉癌组织中的表达及意义。方法：选择喉鳞癌病理标本41例为实验组,另选择距癌组织0.5～1.0cm癌旁正常黏膜组织34例作为对照组,采用采用Western blot(蛋白印迹法)法检测PDCD5在喉鳞癌中的表达,并分析PDCD5的表达与喉鳞癌的病理分化程度、TNM分级、临床分期的关系。结果：PDCD5在实验组中表达阳性率43.9%,对照组为73.5%,两者有显著性差异(P0.05)；PDCD5的阳性表达强度与喉癌的组织学分化程度、TNM分级、临床分期密切相关(均P0.05)。结论：PDCD5阳性表达强度可作为判断喉癌生物学特性的重要指标,PDCD5可作为判断喉癌预后的一个新指标。
[Abstract]:Objective: to investigate the expression and significance of programmed cell death5 (PDCD5) in laryngeal carcinoma. Methods: 41 cases of laryngeal squamous cell carcinoma (LSCC) were selected as experimental group and 34 cases as control group. The expression of PDCD5 in laryngeal squamous cell carcinoma (LSCC) was detected by Western blot (Western blotting). The relationship between the expression of PDCD5 and the pathological differentiation and clinical stage of laryngeal squamous cell carcinoma (LSCC) was analyzed. Results the positive rate of the expression of 7% PDCD5 was 43.9% in the experimental group and 73.5% in the control group. There was a significant difference between the two groups. There was a significant correlation between the positive expression intensity of PDCD5 and the histological differentiation and clinical stage of laryngeal carcinoma (all P 0.05). Conclusion the positive expression intensity of the fraction PDCD5 may be used as an important index to judge the biological characteristics of laryngeal carcinoma. PDCD5 may be a new index to judge the prognosis of laryngeal carcinoma.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R739.65

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