STAT3预测鼻咽癌放疗效应的价值

发布时间：2018-03-15 06:07

本文选题：信号转导和转录激活因子　切入点：鼻咽癌　出处：《临床耳鼻咽喉头颈外科杂志》2014年18期 　论文类型：期刊论文

【摘要】：目的:探讨鼻咽癌肿瘤组织中信号转导和转录激活因子3(STAT3)的表达与鼻咽癌放疗效应的关系,评估STAT3在预测鼻咽癌放疗效应中的价值,为制订个性化的治疗方案提供理论依据。方法:对40例放射敏感和28例放射抵抗的鼻咽癌患者放疗前肿瘤组织中STAT3的蛋白表达情况应用免疫组织化学法进行检测,对STAT3的表达强度及其与放疗效应的关系进行分析,对STAT3在预测鼻咽癌放疗效应的价值进行评估。结果:STAT3在鼻咽癌中总的阳性表达率为100%。在放射治疗敏感的鼻咽癌组织中,9例(22.5%)患者STAT3表达强阳性,31例表达弱阳性;在放射抵抗组,21例(75%)患者STAT3表达强阳性,7例表达弱阳性,两组间表达强度STAT3的差异有统计学意义(χ2=18.414,P0.01)。根据STAT3阳性表达预测鼻咽癌放疗抵抗,敏感性为75.00%,特异性为77.50%,准确率为76.47%,阳性预测值为70.00%,阴性预测值为81.58%,假阳性率为30.00%,假阴性率为18.42%。结论:鼻咽癌肿瘤组织中STAT3的表达强度与肿瘤放射抵抗有关,STAT3对预测鼻咽癌放疗效应有一定的价值,并据此制订出个性化的治疗方案。
[Abstract]:Objective: to investigate the relationship between the expression of signal transduction and transcription activator 3 (STAT3) in nasopharyngeal carcinoma (NPC) and the radiotherapeutic effect of nasopharyngeal carcinoma (NPC), and to evaluate the value of STAT3 in predicting the radiotherapy effect of nasopharyngeal carcinoma (NPC). Methods: the expression of STAT3 protein in tumor tissues of 40 patients with radiosensitivity and 28 patients with radiation resistance before radiotherapy was detected by immunohistochemical method. The expression intensity of STAT3 and its relationship with radiotherapy effect were analyzed. The value of STAT3 in predicting radiotherapy effect of nasopharyngeal carcinoma (NPC) was evaluated. Results the total positive expression rate of STAT3 in nasopharyngeal carcinoma was 1000.The strong positive expression of STAT3 in 9 patients with nasopharyngeal carcinoma was strongly positive and weak positive in 31 patients with radiotherapy sensitive nasopharyngeal carcinoma. In the radiation resistance group (21 cases), 7 cases showed strong positive expression of STAT3 and 7 cases were weakly positive. There was a significant difference in the expression of STAT3 between the two groups (蠂 2 + 18.414 P 0.01). The positive expression of STAT3 was used to predict the radiotherapy resistance of nasopharyngeal carcinoma (NPC). The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, false positive rate, false negative rate and false negative rate of nasopharyngeal carcinoma were 75.00, 77.50, 76.4747, 70.00and 81.58, respectively. Conclusion: the expression of STAT3 in nasopharyngeal carcinoma is related to radiation resistance. It is valuable to measure the radiotherapy effect of nasopharyngeal carcinoma. According to this, the individualized treatment scheme was worked out.
【作者单位】：解放军第163中心医院耳鼻咽喉科;解放军第163中心医院病理科;
【基金】：湖南省卫生厅科研项目(No:C2012-009)
【分类号】：R739.63

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