突发性耳聋患者血清sVCAM-1水平的检测及临床意义

发布时间：2018-03-22 10:57

本文选题：突发性耳聋　切入点：sVCAM-1　出处：《重庆医科大学》2010年硕士论文　论文类型：学位论文

【摘要】： 目的 1.检测突发性耳聋患者血清中sVCAM-1水平。 2.比较不同状况下突发性耳聋患者血清中sVCAM-1表达情况。 3.探讨sVCAM-1在突发性耳聋发病中的可能机制。方法采用酶联免疫法(ELISA)对58例突发性耳聋患者(突聋组)及20例健康人员(对照组)血清中sVCAM-1水平进行检测,并分别按照性别、年龄、听力下降程度、吸烟、饮酒、生活习惯、发病前有无上呼吸道感染史以及有无心脑血管合并症等因素将突发性耳聋患者分组,采用SPSS17.0统计软件处理数据,样本间比较用t检验或one-way ANOVA析,p0.05认为有统计学意义。结果 1.突发性耳聋患者血清中sVCAM-1水平较对照组显著升高,差异显著(p0.0001)。 2.中老年突发性耳聋患者血清中sVCAM-1水平较青年患者显著升高,差异显著(p0.05)。 3.发病前有上呼吸道感染史的突发性耳聋患者血清中sVCAM-1水平较发病前无上呼吸道感染史患者显著升高,差异显著(p0.05)。 4.有心脑血管合并症的突发性耳聋患者血清中sVCAM-1水平较无心脑血管合并症患者显著升高,差异显著(p0.05)。 5.不同性别、听力下降程度、生活习惯以及有无吸烟、饮酒史的突发性耳聋患者血清中sVCAM-1水平无明显差异(p0.05)。结论 1.sVCAM-1可能参与了突发性耳聋的发生发展。 2.年龄、发病前上呼吸道感染史以及心脑血管合并症是影响突发性耳聋患者血清中sVCAM-1水平的重要因素。 3.性别、听力下降程度、吸烟、饮酒、生活习惯对突发性耳聋患者血清中sVCAM-1水平无明显影响。
[Abstract]:Purpose. 1. The serum sVCAM-1 level was measured in patients with sudden deafness. 2. To compare the expression of sVCAM-1 in serum of patients with sudden deafness. 3. To explore the possible mechanism of sVCAM-1 in the pathogenesis of sudden deafness. Method. The serum levels of sVCAM-1 in 58 patients with sudden deafness (sudden deafness group) and 20 healthy persons (control group) were detected by Elisa. The serum sVCAM-1 levels were determined according to sex, age, degree of hearing loss, smoking, drinking and living habits. The patients with sudden deafness were divided into groups with or without the history of upper respiratory tract infection and cardiovascular and cerebrovascular complications before onset, and the data were processed by SPSS17.0 software. T test or one-way ANOVA analysis (p0.05) were used to compare the data among the samples. Results. 1. The serum sVCAM-1 level in patients with sudden deafness was significantly higher than that in the control group (P 0.0001). 2. The serum sVCAM-1 level in the middle and old patients with sudden deafness was significantly higher than that in the young patients (P 0.05). 3. The serum sVCAM-1 level in patients with sudden deafness with history of upper respiratory tract infection before onset was significantly higher than that in patients with no history of upper respiratory tract infection before onset, and the difference was significant (p 0.05). 4. The level of serum sVCAM-1 in patients with sudden deafness with cardio-cerebrovascular complications was significantly higher than that in patients without cardio-cerebrovascular complications (P 0.05). 5. There was no significant difference in serum sVCAM-1 levels among patients with sudden deafness with different gender, hearing loss, living habits, smoking or drinking history. Conclusion. 1.sVCAM-1 may be involved in the development of sudden deafness. 2. Age, history of upper respiratory tract infection prior to onset and cardiovascular and cerebrovascular complications were important factors affecting serum sVCAM-1 level in patients with sudden deafness. 3. Sex, hearing loss, smoking, drinking and living habits had no significant effect on serum sVCAM-1 level in patients with sudden deafness.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R764

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