Graves眼病外周血细胞因子水平与雷公藤多苷干预的影响

发布时间：2018-03-22 19:13

本文选题：Graves眼病(GO)　切入点：雷公藤多苷　出处：《中国中药杂志》2014年03期 　论文类型：期刊论文

【摘要】：探讨Graves眼病(GO)患者外周血细胞因子水平及雷公藤多苷干预的影响。选择64例中重度急性期GO患者。随机分为治疗组与对照组各32例。2组均行基础治疗,对照组联合强的松0.75 mg·kg-1·d-1,逐渐减量(5~10 mg/周),至最小剂量5 mg·d-1。治疗组联合雷公藤多苷20 mg/次,每天3次口服。3个月为1疗程。观察2组治疗前后外周血细胞因子(TNF-α,IL-2,IL-10,IFN-γ)水平及临床疗效。研究表明2组治疗前TNF-α,IL-2,IFN-γ明显高于健康组,IL-10明显低于健康组。治疗后治疗组TNF-α,IL-2,IFN-γ明显降低,而IL-10明显增高(P0.01),治疗后2组比较差异有显著性(P0.01);临床总有效率治疗组88.10%;对照组57.14%(P0.01)2组比较差异有显著性;2组治疗后眼球突出度检测比有显著性差异(P0.01)。结果提示GO患者外周血细胞因子(TNF-α,IL-2,IFN-γ)水平与眼病严重程度呈正相关。雷公藤多苷联合他巴唑治疗GO,具有副作用小、疗效满意等优点。
[Abstract]:To investigate the effect of peripheral blood cytokine level and tripterygium wilfordii polyglycoside intervention in patients with Graves's ophthalmopathy, 64 patients with moderate or severe acute go were randomly divided into treatment group (n = 32) and control group (n = 32). The control group combined with prednisone 0.75 mg kg-1 d-1, gradually reduced the dose of 5 mg/ to the minimum dose of 5 mg 路d -1. The treatment group combined with tripterygium wilfordii for 20 mg/. Three times a day and three months as a course of treatment. The levels of peripheral blood cytokine TNF- 伪 and IL-2IL-10IFN- 纬 were observed before and after treatment in both groups. The results showed that the levels of TNF- 伪 -IL-2tIFN- 纬 before and after treatment were significantly higher in the two groups than those in the healthy control group, and the levels of TNF- 伪 IL-2IFN- 纬 in the treatment group were significantly lower than those in the healthy group before and after treatment, the results showed that the level of TNF- 伪 IL-2IFN- 纬 in the treatment group was significantly lower than that in the control group. IL-10 was significantly higher than that of control group (P 0.01), and there was significant difference between the two groups after treatment (P 0.01); the total clinical effective rate was 88.10 in the treatment group; and in the control group, there was a significant difference between the two groups in the detection of the exophthalmos after treatment (P 0.01). The results indicated that the patients with go had a higher degree of exophthalmos than that of the control group (P 0.01). The level of TNF- 伪 and IL-2IFN- 纬 in peripheral blood was positively correlated with the severity of ophthalmopathy. Satisfactory curative effect and so on.
【作者单位】：金华职业技术学院医学院眼科;浙江省金华市中医院眼科;温州医科大学附属眼视光医院杭州院区屈光手术中心;
【分类号】：R581.1;R771.3

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