经鼻内镜眼眶减压术治疗Graves眼病的Meta分析

发布时间：2018-03-24 16:44

本文选题：眼眶减压术　切入点：Graves眼病　出处：《南京医科大学学报(自然科学版)》2014年09期

【摘要】：目的:系统评价经鼻内镜眼眶减压术治疗Graves眼病的有效性和安全性。方法:检索Medline、Cochrane图书馆临床对照试验资料库中有关经鼻内镜眼眶减压术的随机对照试验或自身对照试验,时限均从建库至2013年5月,并对所获文献的参考文献进行回溯性检索和引文检索。由2位研究者按纳入与排除标准独立进行文献筛选、资料提取和质量评价后,采用RevMan 5.1.0软件进行Meta分析。结果:最终纳入5个自身对照试验,共156例患者。Meta分析结果显示经鼻内镜眼眶内下壁减压术后眼眶突出程度均较术前明显降低,但视力及复视发生率无明显改变。敏感性分析显示本研究结果较稳定。结论:经鼻内镜眼眶减压术可以显著改善Graves眼病的视功能,且引起术后新发复视危险较小。但此结论需进一步由高质量大样本长期随机对照的临床试验来验证。
[Abstract]:Objective: to evaluate the efficacy and safety of transnasal endoscopic orbital decompression in the treatment of Graves ophthalmopathy. Methods: a randomized controlled trial or a self-controlled trial of transnasal endoscopic orbital decompression was conducted in Medline Cochrane Library clinical controlled trial database. The time limit was from the establishment of the database to May 2013, and the retrospective retrieval and citation retrieval of the references were carried out. After the two researchers independently selected the documents according to the inclusion and exclusion criteria, the data were extracted and the quality was evaluated. The results of Meta analysis with RevMan 5.1.0 software showed that the degree of orbital herniation after endoscopic orbital decompression was significantly lower than that before operation. Sensitivity analysis showed that the results of this study were stable. Conclusion: transnasal endoscopic orbital decompression can significantly improve the visual function of Graves's ophthalmopathy. But this conclusion needs to be further verified by long-term randomized trials of high quality and large sample.
【作者单位】：南京医科大学第一附属医院耳鼻咽喉科;
【基金】：南京医科大学第一附属医院临床诊疗新技术新项目江苏省卫生厅科研基金项目(H200904)
【分类号】：R771.3

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