水平方位声源位置改变诱发健康青年人失匹配负波研究

发布时间：2018-03-26 08:05

本文选题：声源定位　切入点：角度辨别阈　出处：《听力学及言语疾病杂志》2015年04期

【摘要】：目的探讨水平方位声源位置改变能否诱发失匹配负波(mismatch negativity,MMN),并定量研究能够诱发出失匹配负波的两个声源间的最小角度,获得一种客观、简便的测试声源定位能力的检测方法。方法在无回声自由声场环境下,利用实验室自主研发的声源定位测试仪(国家专利号200520017252.1)和Bio-logic听觉诱发电位仪,采用oddball听刺激序列和被动听觉模式,以1 000Hz纯音作为刺激声,声源位置的变化作为刺激诱发模式,对30例健康青年受试者按照角度辨别阈法的测试原理引出MMN,记录受试者水平0°、±45°、±90°五个方位的角度辨别阈值(minimum audible angle,MAA)和对应的MMN潜伏期和波幅。结果所有受试者均能成功引出MMN波,不同方位的MAA分别为:MAA(0°)=2.09±1.81°,MAA(-45°)=3.84±1.61°,MAA(45°)=3.69±2.39°,MAA(-90°)=4.41±1.41°,MAA(90°)=4.23±3.22°。其中正前方0°角度辨别阈值最小,与其他方位角度辨别阈值差异有统计学意义。在水平左右对称位置(即-45°与+45°,-90°与+90°),MMN潜伏期、波幅差异无统计学意义。MMN潜伏期随着声源偏侧化程度的增加而延长,组间差异有统计学意义(P0.05),±90°方位诱发MMN波幅较0°和±45°方位处增大,潜伏期延长,差异有统计学意义(P0.05)。结论水平方位声源位置改变可成功诱发失匹配负波,采用失匹配负波研究声源角度辨别阈值,可作为一种客观、简便、定量评估声源定位能力的方法。
[Abstract]:Objective to investigate whether the mismatch negative wave mismatch MMNN can be induced by the change of the position of the sound source in horizontal azimuth, and to quantitatively study the minimum angle between the two sources which can induce the mismatched negative wave, and to obtain an objective sound source. Methods in the absence of echo free sound field, the sound source localization tester (National Patent No. 200520017252.1) and Bio-logic auditory evoked potentiometer (Bio-logic) were used to test the localization ability of sound source in the environment of non-echo free sound field and developed independently by the laboratory (National Patent No. 200520017252.1). Oddball auditory stimulation sequence and passive auditory mode were used, 1 000Hz pure tone was used as stimulus sound, and the change of sound source location was used as stimulus-induced mode. The MMNs were obtained from 30 healthy young subjects according to the principle of the angular discrimination threshold method. The minimum audible threshold and the corresponding MMN latencies and amplitudes were recorded at 0 掳, 卤45 掳, 卤90 掳azimuth, respectively. The results showed that all subjects were able to successfully elicit the MMN wave. The MAA of different azimuth is 2.09 卤1.81 掳MAACA-45 掳/ 3.84 卤1.61 掳MAAMAA 45 掳/ 3.69 卤2.39 掳MAA-90 掳/ 4.41 卤1.41 掳/ 90 掳MAA ~ (90) 卤4.23 卤3.22 掳respectively. There is a significant difference between 0 掳angle in front and other azimuth angles in distinguishing threshold value, the latent period of MMNs in the horizontal and left symmetrical position (-45 掳and 45 掳-90 掳and 90 掳). There was no significant difference in amplitude. The latent period of MMN was prolonged with the increase of the degree of acoustic source lateralization. There was significant difference between the groups (P 0.05). The amplitude of MMN induced by 卤90 掳azimuth was larger than that at 0 掳and 卤45 掳, and the latency was longer than that at 0 掳and 卤45 掳azimuth. Conclusion the mismatched negative wave can be induced successfully by the change of the position of the sound source in horizontal azimuth. Using the mismatched negative wave to study the threshold of acoustic source angle discrimination can be used as an objective, simple and quantitative method to evaluate the location ability of sound source.
【作者单位】：首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科;
【基金】：国家自然科学基金(81271090) 首都卫生发展科研专项项目(2011-2003-02) 首度市民健康项目培育(北京市科委) 北京市教委重点项目(北京市教委) 吴阶平临床科研专项资助基金北京朝阳医院院青年基金联合资助
【分类号】：R764

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