CD44V6和Bcl-2在眼睑部基底细胞癌中的表达及意义

发布时间：2018-03-26 09:29

  本文选题：眼睑部基底细胞癌　切入点：CD44V6　出处：《兰州大学》2011年硕士论文

【摘要】：目的：探讨CD44V6和Bcl-2在眼睑部基底细胞癌中的表达,分析两者之间的相关性。方法：1.利用S-P免疫组化法检测52例眼睑部基底细胞癌组织中CD44V6和Bcl-2蛋白的表达。2.有序多变量资料比较采用Kruskal-Wallis检验,两组之间比较采用x2检验,CD44V6和Bcl-2蛋白相关性分析采用Spearman等级相关。结果：1.CD44V6未分化组阳性率为35.71%,复发组阳性率为57.14%。未分化型与分化型比较、复发组和未复发组比较,CD44V6的表达差异有统计学意义(P0.01)。2.Bcl-2复发组阳性率为57.14%,未复发组阳性率高达97.78%,复发及未复发眼睑部基底细胞癌组间阳性表达率差异有统计学意义。3.CD44V6和Bcl-2在眼睑部基底细胞癌中的表达无相关性。结论：眼睑部基底细胞癌未分化组CD44V6阳性率较高,未复发组Bcl-2阳性率较高,但两者无相关性,提示CD44V6和Bcl-2可能参与了眼睑部基底细胞癌的发生发展过程。
[Abstract]:Objective: to investigate the expression of CD44V6 and Bcl-2 in basal cell carcinoma of eyelid. Methods 1. S-P immunohistochemical method was used to detect the expression of CD44V6 and Bcl-2 protein in 52 cases of eyelid basal cell carcinoma. The ordered multivariate data were compared with Kruskal-Wallis test. The correlation between CD44V6 and Bcl-2 protein was analyzed by Spearman grade correlation between the two groups. Results the positive rate of undifferentiated group was 35.71 and the positive rate of recurrent group was 57.14.The positive rate of undifferentiated type was higher than that of differentiation type. The positive rate of CD44V6 expression in recurrent group was 57.144.The positive rate in non-recurrence group was 97.78. The positive rate of CD44V6 expression in recurrent and non-recurrent eyelid basal cell carcinoma groups was statistically significant. 2. The positive rate of CD44V6 expression in recurrent and non-recurrent eyelid basal cell carcinoma was significantly higher than that in non-recurrence group. There was no correlation between CD44V6 and Bcl-2 expression in eyelid basal cell carcinoma. Conclusion: the positive rate of CD44V6 is higher in undifferentiated group of eyelid basal cell carcinoma. The positive rate of Bcl-2 in non-recurrence group was higher, but there was no correlation between them, suggesting that CD44V6 and Bcl-2 might be involved in the occurrence and development of basal cell carcinoma of eyelid.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R739.7

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