血清热休克蛋白70在突发性聋患者血清中的表达及意义

发布时间：2018-03-27 09:16

本文选题：听觉丧失　切入点：突发性　出处：《实用医学杂志》2014年17期

【摘要】：目的:分析血清热休克蛋白70(HSP70)在突发性聋患者血清中的表达,为临床提供参考依据。方法:以我院收治的50例突发性聋患者为观察组,用酶联免疫吸附法检测血清中HSP70含量,并在治疗过程中对HSP70含量进行监测;与在我院体检的50例健康人(对照组)进行对比。结果:对照组血清HSP70检测水平(0.432±0.023)ng/mL,低于观察组治疗前水平;治疗前观察组中不同耳聋程度患者血清HSP70检测水平呈递增趋势变化,重度者为(0.575±0.053)ng/mL,高于轻、中度患者。治疗过程中,轻、中度耳聋患者血清HSP70降低明显,重度患者较治疗前降低不明显;不同听力恢复程度血清HSP70水平不同,痊愈者HSP70水平明显低于有效者和无效者,并且低于治疗前。结论:HSP70与突发性聋发病有关,耳聋程度、听力恢复程度不同则HSP70表达也不同,HSP70可作为病情评估和预后指标。
[Abstract]:Objective: to analyze the expression of heat shock protein 70 (HSP70) in serum of patients with sudden deafness and to provide reference for clinical application. Methods: 50 patients with sudden deafness were treated in our hospital as observation group, the serum HSP70 content was detected by enzyme linked immunosorbent assay (Elisa). During the course of treatment, the content of HSP70 was monitored and compared with 50 healthy persons (control group). Results: the level of serum HSP70 in the control group was 0.432 卤0.023 ng / mL, which was lower than that before treatment in the observation group. The level of serum HSP70 in patients with different degrees of deafness showed an increasing trend before treatment. The level of serum HSP70 in patients with severe deafness was 0.575 卤0.053 ng / mL, which was higher than that in patients with mild and moderate deafness. During the course of treatment, the levels of serum HSP70 in patients with mild and moderate deafness decreased significantly. The level of serum HSP70 in patients with severe hearing recovery was significantly lower than that in patients with effective and ineffective hearing recovery, and was lower than that before treatment. Conclusion: the level of serum HSP70 is associated with sudden deafness, and the degree of deafness is related to the incidence of sudden deafness. The expression of HSP70 was different with different degree of hearing recovery, and HSP70 could be used as a prognostic index.
【作者单位】：河北省唐山市工人医院耳鼻喉科;
【基金】：唐山市科学技术研究与发展计划指导项目(编号:08130246a)
【分类号】：R764.437

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