MCP-1在增殖性糖尿病视网膜病变玻璃体中的表达

发布时间：2018-03-27 09:28

本文选题：增殖性糖尿病视网膜病变　切入点：玻璃体　出处：《中国医科大学》2010年硕士论文

【摘要】： 目的检测增殖性糖尿病视网膜病变(proliferative diabetic retinopathy, PDR)患者玻璃体中单核细胞趋化蛋白-1(monocyte chemotactic protein-1, MCP-1)的表达水平,探讨其在DR疾病发生发展过程中所发挥的作用。方法应用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测22例PDR患者(实验组)玻璃体中MCP-1的含量,并与15例视网膜脱离患者(疾病对照组)及2例正常人眼(正常对照组)玻璃体中MCP-1的含量进行比较。结果实验组MCP-1的含量为(1316.85±286.402)μg/ml,高于疾病对照组(652.15±410.375)μg/ml以及正常对照组(182.60±77.631)μg/ml。差异有统计学意义(p0.01)。结论 MCP-1在PDR患者玻璃体中存在高表达,提示MCP-1可能参与了糖尿病患者DR的发生发展过程,可能为疾病发生的启动环节或启动环节之一并贯穿始终。
[Abstract]:objective
Objective to detect the expression level of monocyte chemoattractant protein -1 (monocyte chemotactic protein-1, MCP-1) in vitreous body of patients with proliferative diabetic retinopathy (PDR) and to explore its role in the occurrence and development of DR disease.
Method
The application of enzyme linked immunosorbent assay (enzyme-linked immunosorbent, assay, ELISA) were detected in 22 patients with PDR (experimental group) content of vitreous body of MCP-1, and 15 cases of patients with retinal detachment (disease control group) and 2 cases of normal people (normal control group) were compared with the amount of MCP-1 in the vitreous body.
Result
The content of MCP-1 in the experimental group was (1316.85 + 286.402) g/ml, which was higher than that in the disease control group (652.15 + 410.375) g/ml and the normal control group (182.60 + 77.631) g/ml., the difference was statistically significant (P0.01).
conclusion
MCP-1 has high expression in vitreous body of PDR patients, suggesting that MCP-1 may be involved in the occurrence and development of DR in diabetic patients, and may be the starting link or starting link of disease.

【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R774.1

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