江浙沪地区人群中修复基因XRCC1多态性与鼻咽癌易感性的关系

发布时间：2018-03-27 13:26

本文选题：鼻咽肿瘤　切入点：修复基因　出处：《第二军医大学学报》2014年04期

【摘要】：目的探讨我国江浙沪地区人群中DNA损伤修复基因XRCC1多态性与鼻咽癌易感性的关系。方法选取87例江浙沪地区汉族鼻咽癌患者,并随机选取同地区同种族的94例健康者作为对照,两组年龄、性别差异无统计学意义。采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)方法分析研究对象的XRCC1基因Arg194Trp及Arg399Gln两个位点的基因多态性,并比较不同基因型与鼻咽癌发病之间的关系。结果 XRCC1Arg194Trp及Arg399Gln各基因型在鼻咽癌组和对照组间的分布频率基本相同。与携带Arg/Arg基因型者相比携带194位点Trp/Trp基因型者鼻咽癌的发生风险有所降低,但差异无统计学意义(OR=0.41,95%CI:0.08~1.65,P=0.21)。194位点其他基因型以及399位点各基因型对鼻咽癌的发病无明显影响。结论 XRCC1基因194和399位点的单核苷酸多态性可能与鼻咽癌的易感性无关,但194位点的Trp等位基因可能会降低鼻咽癌发病风险。
[Abstract]:Objective to investigate the relationship between DNA damage repair gene XRCC1 polymorphism and susceptibility to nasopharyngeal carcinoma (NPC) in the population of Jiangsu, Zhejiang and Shanghai. Methods Eighty-seven Han nationality patients with nasopharyngeal carcinoma in Jiangsu, Zhejiang and Shanghai were selected and 94 healthy persons of the same race were randomly selected as controls. There was no significant difference in age and sex between the two groups. Restriction fragment length polymorphism polymerase chain reaction polymerase chain reaction (PCR-RFLP) was used to analyze the gene polymorphisms of XRCC1 gene Arg194Trp and Arg399Gln loci. Results the frequencies of XRCC1Arg194Trp and Arg399Gln genotypes in NPC group and control group were almost the same. Compared with those with Arg/Arg genotype, the frequency of Trp/Trp genotype at locus 194 was similar. The risk of nasopharyngeal carcinoma has been reduced, However, there was no significant difference in the incidence of nasopharyngeal carcinoma between the two genotypes. Conclusion the single nucleotide polymorphisms of XRCC1 gene 194 and 399locus may not be associated with the susceptibility of nasopharyngeal carcinoma. However, the Trp allele at locus 194 may reduce the risk of nasopharyngeal carcinoma.
【作者单位】：第二军医大学长征医院耳鼻咽喉科;
【基金】：国家自然科学基金青年科学基金(81300837)~~
【分类号】：R739.63

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